タイトル | Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases. |
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ジャーナル・号・ページ | J. Mol. Biol., Vol. 429, Page 1554-1569, Year 2017 |
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掲載日 | 2016年2月4日 (構造データの登録日) |
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著者 | Faille, A. / Gavalda, S. / Slama, N. / Lherbet, C. / Maveyraud, L. / Guillet, V. / Laval, F. / Quemard, A. / Mourey, L. / Pedelacq, J.D. |
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リンク | J. Mol. Biol. / PubMed:28377293 |
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手法 | X線回折 |
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解像度 | 1.6 - 3.197 Å |
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構造データ | PDB-5i0k: Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases 手法: X-RAY DIFFRACTION / 解像度: 3.197 Å PDB-5l84: Structure of the H959F variant of the PpsC dehydratase domain from Mycobacterium tuberculosis 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-5nji: Structure of the dehydratase domain of PpsC from Mycobacterium tuberculosis in complex with C12:1-CoA 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å |
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化合物 | ChemComp-8Z2: ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (~{E})-dodec-2-enethioate
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由来 | ![](img/tx_bacteria.gif) mycobacterium tuberculosis (結核菌)
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キーワード | TRANSFERASE / dehydratase / polyketide / complex / tuberculosis |
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