EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.
ジャーナル・号・ページ	Mol. Cell, Vol. 65, Page 644-658.e5, Year 2017
掲載日	2016年6月1日 (構造データの登録日)
著者	Choy, M.S. / Li, Y. / Machado, L.E. / Kunze, M.B. / Connors, C.R. / Wei, X. / Lindorff-Larsen, K. / Page, R. / Peti, W.
リンク	Mol. Cell / PubMed:28212750
手法	X線回折
解像度	1.84 - 2.185 Å
構造データ	PDB-5k9v: Protein Tyrosine Phosphatase 1B (1-301), open state 手法: X-RAY DIFFRACTION / 解像度: 1.898 Å PDB-5k9w: Protein Tyrosine Phosphatase 1B (1-301) in complex with TCS401, closed state 手法: X-RAY DIFFRACTION / 解像度: 2.01 Å PDB-5ka0: Protein Tyrosine Phosphatase 1B Delta helix 7, open state 手法: X-RAY DIFFRACTION / 解像度: 1.991 Å PDB-5ka1: Protein Tyrosine Phosphatase 1B Delta helix 7 mutant in complex with TCS401, closed state 手法: X-RAY DIFFRACTION / 解像度: 1.84 Å PDB-5ka2: Protein Tyrosine Phosphatase 1B YAYA (Y152A, Y153A) mutant, open state 手法: X-RAY DIFFRACTION / 解像度: 2.071 Å PDB-5ka3: Protein Tyrosine Phosphatase 1B YAYA (Y152A, Y153A) mutant in complex with TCS401, closed state 手法: X-RAY DIFFRACTION / 解像度: 2.141 Å PDB-5ka4: Protein Tyrosine Phosphatase 1B T178A mutant, open state 手法: X-RAY DIFFRACTION / 解像度: 2.185 Å PDB-5ka7: Protein Tyrosine Phosphatase 1B T178A mutant in complex with TCS401, closed state 手法: X-RAY DIFFRACTION / 解像度: 2.061 Å PDB-5ka8: Protein Tyrosine Phosphatase 1B L192A mutant, open state 手法: X-RAY DIFFRACTION / 解像度: 1.971 Å PDB-5ka9: Protein Tyrosine Phosphatase 1B L192A mutant in complex with TCS401, open state 手法: X-RAY DIFFRACTION / 解像度: 2.07 Å PDB-5kaa: Protein Tyrosine Phosphatase 1B Delta helix 7, P185G mutant, open state 手法: X-RAY DIFFRACTION / 解像度: 1.968 Å PDB-5kab: Protein Tyrosine Phosphatase 1B Delta helix 7, P185G mutant in complex with TCS401, open state 手法: X-RAY DIFFRACTION / 解像度: 1.968 Å PDB-5kac: Protein Tyrosine Phosphatase 1B P185G mutant, open state 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5kad: Protein Tyrosine Phosphatase 1B N193A mutant in complex with TCS401, closed state 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å
化合物	ChemComp-CL: Unknown entry / クロリド ChemComp-TRS: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / トリス(ヒドロキシメチル)メチルアンモニウム / pH緩衝剤YM ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-HOH: WATER ChemComp-OTA: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID / 2-[(1,2-ジオキソ-2-ヒドロキシエチル)アミノ]-4,5,6,7-テトラヒドロチエノ[2,3-c]ピリジン-3(以下略) ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM
由来	homo sapiens (ヒト)
キーワード	HYDROLASE / Protein tyrosine phosphatase / hydrolase/hydrolase inhibitor / hydrolase-hydrolase inhibitor complex