EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
ジャーナル・号・ページ	Chemmedchem, Vol. 11, Page 2024-2036, Year 2016
掲載日	2016年4月12日 (構造データの登録日)
著者	Sooriyaarachchi, S. / Chofor, R. / Risseeuw, M.D. / Bergfors, T. / Pouyez, J. / Dowd, C.S. / Maes, L. / Wouters, J. / Jones, T.A. / Van Calenbergh, S. / Mowbray, S.L.
リンク	Chemmedchem / PubMed:27487410
手法	X線回折
解像度	1.4 - 1.8 Å
構造データ	PDB-5jaz: Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC51 and manganese 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-5jbi: Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC52 and manganese 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-5jc1: Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC55 and manganese 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-5jmp: Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC57 and manganese 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-5jmw: Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC50 and manganese 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-5jnl: Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC54 and manganese 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-5jo0: Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC56 and manganese 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å
化合物	ChemComp-LC5: [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(naphthalen-1-yl)pentyl]phosphonic acid ChemComp-MN: Unknown entry ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-FMT: FORMIC ACID / ギ酸 ChemComp-HOH: WATER ChemComp-6J8: [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(4-methoxyphenyl)pentyl]phosphonic acid ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-6JB: [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(3-methoxyphenyl)pentyl]phosphonic acid ChemComp-LC7: [(2R)-5-(3-fluorophenyl)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}pentyl]phosphonic acid ChemComp-6LB: 4-ethylmorpholine / 4-エチルモルホリン ChemComp-L50: [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(4-methylphenyl)pentyl]phosphonic acid ChemComp-MPD: (4S)-2-METHYL-2,4-PENTANEDIOL / (S)-2-メチル-2,4-ペンタンジオ-ル / 沈殿剤YM ChemComp-L54: {(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-[4-(trifluoromethyl)phenyl]pentyl}phosphonic acid ChemComp-L56: [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(3-methylphenyl)pentyl]phosphonic acid ChemComp-6LR*: morpholine / モルホリン
由来	plasmodium falciparum (isolate 3d7) (マラリア病原虫) plasmodium falciparum 3d7 (マラリア病原虫)
キーワード	OXIDOREDUCTASE / ENZYME-INHIBITOR COMPLEX / MEP PATHWAY / ISOPRENOID BIOSYNTHESIS