タイトル | Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase. |
---|
ジャーナル・号・ページ | Biochemistry, Vol. 55, Page 2864-2874, Year 2016 |
---|
掲載日 | 2016年3月6日 (構造データの登録日) |
---|
著者 | Chen, M. / Chou, W.K. / Al-Lami, N. / Faraldos, J.A. / Allemann, R.K. / Cane, D.E. / Christianson, D.W. |
---|
リンク | Biochemistry / PubMed:27172425 |
---|
手法 | X線回折 |
---|
解像度 | 1.95 - 2.527 Å |
---|
構造データ | PDB-5imi: Crystal structure of S303A Aspergillus terreus aristolochene synthase complexed with (1S,8S,9aR)-1,9a-dimethyl-8-(prop-1-en-2-yl)decahydroquinolizin-5-ium 手法: X-RAY DIFFRACTION / 解像度: 2.462 Å PDB-5imn: Crystal structure of N299A/S303A Aspergillus terreus aristolochene synthase complexed with (1S,8S,9aR)-1,9a-dimethyl-8-(prop-1-en-2-yl)decahydroquinolizin-5-ium 手法: X-RAY DIFFRACTION / 解像度: 2.527 Å PDB-5imp: Crystal structure of N299A Aspergillus terreus aristolochene synthase complexed with (1S,8S,9aR)-1,9a-dimethyl-8-(prop-1-en-2-yl)decahydroquinolizin-5-ium 手法: X-RAY DIFFRACTION / 解像度: 2.038 Å PDB-5in8: Crystal structure of Q151H Aspergillus terreus aristolochene synthase 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-5ivg: Crystal structure of Aspergillus terreus aristolochene synthase N299A complexed with farnesyl thiolodiphosphate 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å |
---|
化合物 | ChemComp-JF1: (1S,5S,8S,9aR)-1,9a-dimethyl-8-(prop-1-en-2-yl)octahydro-2H-quinolizinium
|
---|
由来 | ![](img/tx_fungus.gif) aspergillus terreus (カビ)
|
---|
キーワード | LYASE/LYASE INHIBITOR / Lyase / terpene cyclases / LYASE-LYASE INHIBITOR complex |
---|