EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA
ジャーナル・号・ページ	To Be Published
掲載日	2016年2月25日 (構造データの登録日)
著者	Pierce, P. / Muruthi, M.M. / Abendroth, J. / Moen, S.O. / Begley, D.W. / Davies, D.R. / Marathias, V.M. / Staker, B.L. / Myler, P.J. / Lorimer, D.D. / Edwards, T.E.
リンク	PubMedで検索
手法	X線回折
解像度	2.2 - 2.65 Å
構造データ	PDB-5ieq: Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-747 1-(4-chlorophenyl)-1H-imidazole 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-5if2: Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-576 (5,6-dichloro-1H-1,3-benzodiazol-2-yl)methanol 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-5if5: Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to EBSI-39 (2,3-dichlorophenyl)methanol 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-5if7: Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-279 N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-5if8: Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-2643 5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-5ifb: Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4719 5-chloro-2-(1H-imidazol-1-yl)aniline 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-5ifc: Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4720 1-(4-bromophenyl)-1H-imidazole 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-5ifd: Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4721 1-(4-fluorophenyl)-1H-imidazole 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å
化合物	ChemComp-1CI: 1-(4-CHLOROPHENYL)-1H-IMIDAZOLE / 1-(4-クロロフェニル)-1H-イミダゾ-ル ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-HOH: WATER ChemComp-6B1: (5,6-dichloro-1H-benzimidazol-2-yl)methanol / 5,6-ジクロロ-2-ヒドロキシメチル-1H-ベンゾイミダゾ-ル ChemComp-CL: Unknown entry / クロリド ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-6B0: (2,3-dichlorophenyl)methanol / 2,3-ジクロロベンジルアルコ-ル ChemComp-6AY: N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine ChemComp-6AX: 5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-6AV: 5-chloro-2-(1H-imidazol-1-yl)aniline ChemComp-6AR: 1-(4-bromophenyl)-1H-imidazole / 1-(4-ブロモフェニル)-1H-イミダゾ-ル ChemComp-6AQ*: 1-(4-fluorophenyl)-1H-imidazole / 1-(4-フルオロフェニル)-1H-イミダゾ-ル
由来	influenza a virus (strain a/wilson-smith/1933 h1n1) (A型インフルエンザウイルス)
キーワード	VIRAL PROTEIN / NIAID / structural genomics / fragment screening / STD NMR / fragments of life / flu / Seattle Structural Genomics Center for Infectious Disease / SSGCID / RdRp / polymerase