EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics.
ジャーナル・号・ページ	Mol. Cancer Ther., Vol. 16, Page 1054-1067, Year 2017
掲載日	2015年12月4日 (構造データの登録日)
著者	Ember, S.W. / Lambert, Q.T. / Berndt, N. / Gunawan, S. / Ayaz, M. / Tauro, M. / Zhu, J.Y. / Cranfill, P.J. / Greninger, P. / Lynch, C.C. ...Ember, S.W. / Lambert, Q.T. / Berndt, N. / Gunawan, S. / Ayaz, M. / Tauro, M. / Zhu, J.Y. / Cranfill, P.J. / Greninger, P. / Lynch, C.C. / Benes, C.H. / Lawrence, H.R. / Reuther, G.W. / Lawrence, N.J. / Schonbrunn, E.
リンク	Mol. Cancer Ther. / PubMed:28336808
手法	X線回折
解像度	1.35 - 1.76 Å
構造データ	PDB-5f5z: Crystal structure of the first bromodomain of human BRD4 in complex with MA2-014 手法: X-RAY DIFFRACTION / 解像度: 1.76 Å PDB-5f60: Crystal structure of the first bromodomain of human BRD4 in complex with SG3-014 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-5f61: Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-1 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-5f62: Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-2 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-5f63: Crystal structure of the first bromodomain of human BRD4 in complex with SG3-179 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å
化合物	ChemComp-5VY: 2-methyl-~{N}-[3-[[5-methyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]amino]phenyl]propane-2-sulfonamide ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-HOH: WATER ChemComp-5VZ: ~{N}-[2-chloranyl-5-[[5-methyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]amino]phenyl]-2-methyl-propane-2-sulfonamide ChemComp-PEG: DI(HYDROXYETHYL)ETHER / ジエチレングリコ-ル ChemComp-5W0: ~{N}-[3-[[2-[[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-pyrimidin-4-yl]amino]phenyl]-2-methyl-propane-2-sulfonamide ChemComp-5W1: ~{N}-[2-chloranyl-5-[[2-[[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-pyrimidin-4-yl]amino]phenyl]-2-methyl-propane-2-sulfonamide ChemComp-5W2: 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{N}-(1-methylpiperidin-4-yl)benzamide
由来	homo sapiens (ヒト)
キーワード	TRANSCRIPTION/TRANSCRIPTION INHIBITOR / BROMODOMAIN / CAP / HUNK1 / MCAP / PROTEIN BINDING-INHIBITOR COMPLEX / MITOTIC CHROMOSOME ASSOCIATED PROTEIN / CELL CYCLE / INHIBITOR / TRANSCRIPTION-INHIBITOR COMPLEX / TRANSCRIPTION-TRANSCRIPTION INHIBITOR complex / ROMODOMAIN