タイトル | THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria. |
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ジャーナル・号・ページ | Nat Microbiol, Vol. 1, Page 15006-15006, Year 2016 |
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掲載日 | 2015年9月18日 (構造データの登録日) |
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著者 | Cox, J.A. / Abrahams, K.A. / Alemparte, C. / Ghidelli-Disse, S. / Rullas, J. / Angulo-Barturen, I. / Singh, A. / Gurcha, S.S. / Nataraj, V. / Bethell, S. ...Cox, J.A. / Abrahams, K.A. / Alemparte, C. / Ghidelli-Disse, S. / Rullas, J. / Angulo-Barturen, I. / Singh, A. / Gurcha, S.S. / Nataraj, V. / Bethell, S. / Remuinan, M.J. / Encinas, L. / Jervis, P.J. / Cammack, N.C. / Bhatt, A. / Kruse, U. / Bantscheff, M. / Futterer, K. / Barros, D. / Ballell, L. / Drewes, G. / Besra, G.S. |
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リンク | Nat Microbiol / PubMed:27571973 |
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手法 | X線回折 |
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解像度 | 1.5 - 2.704 Å |
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構造データ | PDB-5dtp: Crystal structure of M. tuberculosis EchA6 (apo, trigonal crystal form) 手法: X-RAY DIFFRACTION / 解像度: 1.91 Å PDB-5dtw: Crystal structure of M. tuberculosis EchA6 bound to C20-CoA 手法: X-RAY DIFFRACTION / 解像度: 2.439 Å PDB-5du4: Crystal structure of M. tuberculosis EchA6 bound to ligand GSK366A 手法: X-RAY DIFFRACTION / 解像度: 1.702 Å PDB-5du6: Crystal structure of M. tuberculosis EchA6 bound to ligand GSK059A. 手法: X-RAY DIFFRACTION / 解像度: 2.61 Å PDB-5du8: Crystal structure of M. tuberculosis EchA6 bound to GSK572A 手法: X-RAY DIFFRACTION / 解像度: 2.23 Å PDB-5duc: Crystal structure of M. tuberculosis EchA6 bound to ligand GSK951A 手法: X-RAY DIFFRACTION / 解像度: 2.704 Å PDB-5duf: Crystal structure of M. tuberculosis EchA6 bound to ligand GSK729A 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å |
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化合物 | ChemComp-5FF: (5R,7S)-5-(4-ethylphenyl)-N-(4-methoxybenzyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
ChemComp-G59: (5R,7R)-5-(4-ethylphenyl)-N-(4-fluorobenzyl)-7-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
ChemComp-5FK: (5R,7S)-5-(4-ethylphenyl)-N-[(5-fluoropyridin-2-yl)methyl]-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
ChemComp-G51: (5R,7S)-N-(1,3-benzodioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
ChemComp-G7A: (5R,7S)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid
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由来 | mycobacterium tuberculosis (strain atcc 25618 / h37rv) (結核菌)![](img/tx_bacteria.gif) mycobacterium tuberculosis (結核菌)
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キーワード | LIPID BINDING PROTEIN / enoyl-CoA hydratase-like / lyase |
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