タイトル | Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. |
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ジャーナル・号・ページ | Sci Rep, Vol. 6, Page 28528-28528, Year 2016 |
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掲載日 | 2015年9月9日 (構造データの登録日) |
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著者 | Janecek, M. / Rossmann, M. / Sharma, P. / Emery, A. / Huggins, D.J. / Stockwell, S.R. / Stokes, J.E. / Tan, Y.S. / Almeida, E.G. / Hardwick, B. ...Janecek, M. / Rossmann, M. / Sharma, P. / Emery, A. / Huggins, D.J. / Stockwell, S.R. / Stokes, J.E. / Tan, Y.S. / Almeida, E.G. / Hardwick, B. / Narvaez, A.J. / Hyvonen, M. / Spring, D.R. / McKenzie, G.J. / Venkitaraman, A.R. |
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リンク | Sci Rep / PubMed:27339427 |
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手法 | X線回折 |
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解像度 | 1.95 - 2.98 Å |
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構造データ | PDB-5dn3: Aurora A in complex with ATP and AA35. 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-5dnr: Aurora A Kinase in complex with ATP in space group P41212 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-5dos: Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122 手法: X-RAY DIFFRACTION / 解像度: 2.98 Å PDB-5dpv: Aurora A Kinase in Complex with AA35 and JNJ-7706621 in Space Group P6122 手法: X-RAY DIFFRACTION / 解像度: 2.285 Å PDB-5dr2: Aurora A Kinase in Complex with AA30 and ATP in Space Group P6122 手法: X-RAY DIFFRACTION / 解像度: 2.46 Å PDB-5dr6: Aurora A Kinase in Complex with AA30 and JNJ-7706621 in Space Group P6122 手法: X-RAY DIFFRACTION / 解像度: 2.534 Å PDB-5dr9: Aurora A Kinase in Complex with AA29 and JNJ-7706621 in Space Group P6122 手法: X-RAY DIFFRACTION / 解像度: 2.47 Å PDB-5drd: Aurora A Kinase in Complex with ATP in Space Group P6122 手法: X-RAY DIFFRACTION / 解像度: 2.13 Å PDB-5dt0: Aurora A Kinase in Complex with JNJ-7706621 in Space Group P6122 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-5dt3: Aurora A Kinase in Complex with ATP in Space Group P6122 手法: X-RAY DIFFRACTION / 解像度: 2.33 Å PDB-5dt4: Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122 手法: X-RAY DIFFRACTION / 解像度: 2.86 Å |
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化合物 | ChemComp-5DN: 2-(3-bromophenyl)-8-fluoroquinoline-4-carboxylic acid
ChemComp-SKE: 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide / JNJ-7706621
ChemComp-5E1: 2-(3-bromophenyl)quinoline-4-carboxylic acid
ChemComp-5E2: 2-(3-bromophenyl)-6-chloroquinoline-4-carboxylic acid
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / Aurora A kinase / mitotic kinase / PPI |
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