EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
ジャーナル・号・ページ	Cancer Res., Vol. 75, Page 3340-, Year 2015
掲載日	2015年9月14日 (構造データの登録日)
著者	Gurden, M.D. / Westwood, I.M. / Faisal, A. / Naud, S. / Cheung, K.J. / Mcandrew, C. / Wood, A. / Schmitt, J. / Boxall, K. / Mak, G. ...Gurden, M.D. / Westwood, I.M. / Faisal, A. / Naud, S. / Cheung, K.J. / Mcandrew, C. / Wood, A. / Schmitt, J. / Boxall, K. / Mak, G. / Workman, P. / Burke, R. / Hoelder, S. / Blagg, J. / Van Montfort, R.L.M. / Linardopoulos, S.
リンク	Cancer Res. / PubMed:26202014
手法	X線回折
解像度	2.05 - 2.85 Å
構造データ	PDB-5ap0: Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-5ap1: Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-5ap2: Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-5ap3: Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-5ap4: Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. 手法: X-RAY DIFFRACTION / 解像度: 2.85 Å PDB-5ap5: Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-5ap6: Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-5ap7: Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å
化合物	ChemComp-AU5: 9-CYCLOPENTYL-2-[[2-METHOXY-4-[(1-METHYLPIPERIDIN-4-YL)OXY]-PHENYL]AMINO]-7-METHYL-7,9-DIHYDRO-8H-PURIN-8-ONE / AZ-3146 ChemComp-P4C: O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL / 20-ヒドロキシ-3,6,9,12,15,18-ヘキサオキサイコサン-1-オン ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-HOH: WATER ChemComp-O38: 6-{[3-(cyanomethoxy)-4-(1-methyl-1H-pyrazol-4-yl)phenyl]amino}-2-(cyclohexylamino)pyridine-3-carbonitrile ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-PWU: ISOPROPYL 6-((4-(1,2-DIMETHYL-1H-IMIDAZOL-5-YL)PHENYL)AMINO)-2-(1-METHYL-1H-PYRAZOL-4-YL)-1H-PYRROLO[3,2-C]PYRIDINE-1-CARBOXYLATE ChemComp-7PE: 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL / 3,6,9,12,15,18-ヘキサオキサイコサン-1-オ-ル ChemComp-7RO: tert-butyl 6-((2-chloro-4-(dimethylcarbamoyl)phenyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate / 6-[2-クロロ-4-(ジメチルカルバモイル)アニリノ]-2-(1-メチル-1H-ピラゾ-ル-4-イル)-1H-ピロロ(以下略) ChemComp-1KA: (2-hydroxyethoxy)acetaldehyde ChemComp-PGE: TRIETHYLENE GLYCOL / トリエチレングリコ-ル ChemComp-SVE*: N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / MPS1 / PROTEIN KINASE / MITOSIS / DRUG RESISTANCE