タイトル | Discovery of Inhibitors for the Ether Lipid-Generating Enzyme Agps as Anti-Cancer Agents. |
---|
ジャーナル・号・ページ | Acs Chem. Biol., Vol. 10, Page 2589-, Year 2015 |
---|
掲載日 | 2015年8月25日 (構造データの登録日) |
---|
著者 | Piano, V. / Benjamin, D.I. / Valente, S. / Nenci, S. / Marrocco, B. / Mai, A. / Aliverti, A. / Nomura, D.K. / Mattevi, A. |
---|
リンク | Acs Chem. Biol. / PubMed:26322624 |
---|
手法 | X線回折 |
---|
解像度 | 2 - 2.2 Å |
---|
構造データ | PDB-5adz: Ether Lipid-Generating Enzyme AGPS in complex with inhibitor 1a 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-5ae1: Ether Lipid-Generating Enzyme AGPS in complex with inhibitor ZINC69435460 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-5ae2: Ether Lipid-Generating Enzyme AGPS in complex with inhibitor 1e 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5ae3: Ether Lipid-Generating Enzyme AGPS in complex with antimycin A 手法: X-RAY DIFFRACTION / 解像度: 2.18 Å |
---|
化合物 | ChemComp-KQS: (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide)
ChemComp-B2Z: (3-(2-FLUOROPHENYL)-N-(1-(2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-5-YL)ETHYL)BUTANAMIDE)
ChemComp-FYC: 3-(2-fluorophenyl)-2-methyl-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)acrylamide
ChemComp-AWB: [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 3-methylbutanoate / アンチマイシンA1b
|
---|
由来 | - cavia porcellus (哺乳類)
|
---|
キーワード | TRANSFERASE / ETHER PHOSPHOLIPID / CANCER / FLAVIN |
---|