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-Structure paper
タイトル | A Selective and Brain Penetrant p38 alpha MAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 62, Page 5298-5311, Year 2019 |
掲載日 | 2012年4月27日 (構造データの登録日) |
![]() | Roy, S.M. / Minasov, G. / Arancio, O. / Chico, L.W. / Van Eldik, L.J. / Anderson, W.F. / Pelletier, J.C. / Watterson, D.M. |
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手法 | X線回折 |
解像度 | 2.1 - 2.15 Å |
構造データ | ![]() PDB-4ewq: ![]() PDB-4zth: |
化合物 | ![]() ChemComp-GG5: ![]() ChemComp-MWL: ![]() ChemComp-ZN: ![]() ChemComp-CL: ![]() ChemComp-BME: ![]() ChemComp-GOL: ![]() ChemComp-ACT: ![]() ChemComp-PEG: ![]() ChemComp-HOH: ![]() ChemComp-VVT: |
由来 |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / Serine/Threonine-protein kinase / Structural Genomics / Center for Structural Genomics of Infectious Diseases / CSGID / Protein Kinase Domain / Transferase / ATP Binding / Phosphorylation / Cytosol / TRANSFERASE-TRANSFERASE INHIBITOR complex |