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-Structure paper
タイトル | Structures of the bacterial ribosome at 3.5 A resolution. |
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ジャーナル・号・ページ | Science, Vol. 310, Issue 5749, Page 827-834, Year 2005 |
掲載日 | 2005年11月4日 |
![]() | Barbara S Schuwirth / Maria A Borovinskaya / Cathy W Hau / Wen Zhang / Antón Vila-Sanjurjo / James M Holton / Jamie H Doudna Cate / ![]() |
PubMed 要旨 | We describe two structures of the intact bacterial ribosome from Escherichia coli determined to a resolution of 3.5 angstroms by x-ray crystallography. These structures provide a detailed view of the ...We describe two structures of the intact bacterial ribosome from Escherichia coli determined to a resolution of 3.5 angstroms by x-ray crystallography. These structures provide a detailed view of the interface between the small and large ribosomal subunits and the conformation of the peptidyl transferase center in the context of the intact ribosome. Differences between the two ribosomes reveal a high degree of flexibility between the head and the rest of the small subunit. Swiveling of the head of the small subunit observed in the present structures, coupled to the ratchet-like motion of the two subunits observed previously, suggests a mechanism for the final movements of messenger RNA (mRNA) and transfer RNAs (tRNAs) during translocation. |
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手法 | X線回折 |
解像度 | 3.46 Å |
構造データ | ![]() PDB-4v4q: |
化合物 | ![]() ChemComp-MG: ![]() ChemComp-HOH: |
由来 |
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![]() | RIBOSOME / RNA-protein complex / 30S RIBOSOMAL SUBUNIT |