EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
ジャーナル・号・ページ	Eur. J. Med. Chem., Vol. 86C, Page 352-, Year 2014
掲載日	2014年8月5日 (構造データの登録日)
著者	Vianello, P. / Botrugno, O.A. / Cappa, A. / Ciossani, G. / Dessanti, P. / Mai, A. / Mattevi, A. / Meroni, G. / Minucci, S. / Thaler, F. ...Vianello, P. / Botrugno, O.A. / Cappa, A. / Ciossani, G. / Dessanti, P. / Mai, A. / Mattevi, A. / Meroni, G. / Minucci, S. / Thaler, F. / Tortorici, M. / Trifiro, P. / Valente, S. / Villa, M. / Varasi, M. / Mercurio, C.
リンク	Eur. J. Med. Chem. / PubMed:25173853
手法	X線回折
解像度	2.8 - 3.1 Å
構造データ	PDB-4uv8: LSD1(KDM1A)-CoREST in complex with 1-Benzyl-Tranylcypromine 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-4uv9: LSD1(KDM1A)-CoREST in complex with 1-Ethyl-Tranylcypromine 手法: X-RAY DIFFRACTION / 解像度: 3.0 Å PDB-4uva: LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1R,2S) 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-4uvb: LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R) 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-4uvc: LSD1(KDM1A)-CoREST in complex with 1-Phenyl-Tranylcypromine 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å
化合物	ChemComp-D69: [[(2R,3S,4S)-5-[(4aS,10aS)-4a-[(1S)-3-azanylidene-1,4-diphenyl-butyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-5,10a-dihydro-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentoxy]-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate ChemComp-HOH: WATER / 水 ChemComp-D70: [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS,10aS)-4a-[(1S,3E)-3-imino-1-phenylpentyl]-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate ChemComp-D73: [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS)-4a-[(1S,3E)-3-imino-1-phenylbutyl]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate ChemComp-D51: [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,7aS)-1-amino-1,10,11-trimethyl-4,6-dioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate ChemComp-D52: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-[5-[(1S)-1-azanyl-1,3-diphenyl-propyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-4aH-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate
由来	homo sapiens (ヒト)
キーワード	TRANSCRIPTION (転写 (生物学)) / COVALENT INHIBITOR / HISTONE DEMETHYLASE