タイトル | Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide. |
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ジャーナル・号・ページ | Nature, Vol. 517, Page 635-639, Year 2015 |
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掲載日 | 2014年8月11日 (構造データの登録日) |
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著者 | Freudenthal, B.D. / Beard, W.A. / Perera, L. / Shock, D.D. / Kim, T. / Schlick, T. / Wilson, S.H. |
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リンク | Nature / PubMed:25409153 |
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手法 | X線回折 |
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解像度 | 1.88 - 2.51 Å |
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構造データ | PDB-4uaw: DNA polymerase beta substrate complex with a templating adenine and incoming 8-oxodGTP, 0 s 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-4uay: DNA polymerase beta product complex with a templating adenine and inserted 8-oxodGMP, 40 s 手法: X-RAY DIFFRACTION / 解像度: 1.984 Å PDB-4uaz: DNA polymerase beta reactant complex with a templating adenine and incoming 8-oxodGTP, 20 s 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-4ub1: DNA polymerase beta product complex with a templating adenine and 8-oxodGMP, 90 s 手法: X-RAY DIFFRACTION / 解像度: 2.341 Å PDB-4ub2: DNA polymerase beta product complex with a templating cytosine and 8-oxodGMP, 120 s 手法: X-RAY DIFFRACTION / 解像度: 2.51 Å PDB-4ub3: DNA polymerase beta closed product complex with a templating cytosine and 8-oxodGMP, 60 s 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å PDB-4ub4: DNA polymerase beta substrate complex with a templating cytosine and incoming dGTP, 0 s 手法: X-RAY DIFFRACTION / 解像度: 1.954 Å PDB-4ub5: DNA polymerase beta substrate complex with a templating cytosine, incoming 8-oxodGTP, and Mn2+, 5 s 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-4ubb: DNA polymerase beta reactant complex with a templating cytosine and incoming 8-oxodGTP, 40 s 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-4ubc: DNA polymerase beta substrate complex with a templating cytosine and incoming 8-oxodGTP, 0 s 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å |
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化合物 | |
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由来 | homo sapiens (ヒト)- synthetic construct (人工物)
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キーワード | TRANSFERASE / LYASE/DNA / DNA polymerase / LYASE-DNA complex |
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