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-Structure paper
タイトル | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 57, Page 10176-10191, Year 2014 |
掲載日 | 2014年10月8日 (構造データの登録日) |
![]() | Hanan, E.J. / Eigenbrot, C. / Bryan, M.C. / Burdick, D.J. / Chan, B.K. / Chen, Y. / Dotson, J. / Heald, R.A. / Jackson, P.S. / La, H. ...Hanan, E.J. / Eigenbrot, C. / Bryan, M.C. / Burdick, D.J. / Chan, B.K. / Chen, Y. / Dotson, J. / Heald, R.A. / Jackson, P.S. / La, H. / Lainchbury, M.D. / Malek, S. / Purkey, H.E. / Schaefer, G. / Schmidt, S. / Seward, E.M. / Sideris, S. / Tam, C. / Wang, S. / Yeap, S.K. / Yen, I. / Yin, J. / Yu, C. / Zilberleyb, I. / Heffron, T.P. |
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手法 | X線回折 |
解像度 | 1.63 - 3.1 Å |
構造データ | ![]() PDB-4rj3: ![]() PDB-4rj4: ![]() PDB-4rj5: ![]() PDB-4rj6: ![]() PDB-4rj7: ![]() PDB-4rj8: |
化合物 | ![]() ChemComp-ACT: ![]() ChemComp-3QS: ![]() ChemComp-HOH: ![]() ChemComp-3QW: ![]() ChemComp-3QY: ![]() ChemComp-SO4: ![]() ChemComp-3R0: ![]() ChemComp-3R1: |
由来 |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / protein kinase / phosphotransfer catalyst / lysine acetylation / TRANSFERASE-TRANSFERASE INHIBITOR complex |