EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents.
ジャーナル・号・ページ	J. Med. Chem., Vol. 58, Page 827-846, Year 2015
掲載日	2014年9月10日 (構造データの登録日)
著者	Keough, D.T. / Hockova, D. / Janeba, Z. / Wang, T.H. / Naesens, L. / Edstein, M.D. / Chavchich, M. / Guddat, L.W.
リンク	J. Med. Chem. / PubMed:25494538
手法	X線回折
解像度	1.871 - 2.549 Å
構造データ	PDB-4rab: Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents 手法: X-RAY DIFFRACTION / 解像度: 2.264 Å PDB-4rac: Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-4rad: Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-4ran: Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents 手法: X-RAY DIFFRACTION / 解像度: 2.549 Å PDB-4rao: Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents 手法: X-RAY DIFFRACTION / 解像度: 1.871 Å PDB-4raq: Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents 手法: X-RAY DIFFRACTION / 解像度: 2.53 Å
化合物	ChemComp-3L3: [(E)-2-(2-{[2-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)ethenyl]phosphonic acid ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-PO4: PHOSPHATE ION / ホスファ-ト ChemComp-HOH: WATER ChemComp-3L4: [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid ChemComp-3L5: (2-{[2-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)ethyl][2-(2-phosphonoethoxy)ethyl]amino}ethyl)phosphonic acid ChemComp-3L6: (2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](3-aminopropyl)amino}ethyl)phosphonic acid ChemComp-3L7: (2-{[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](2-{[(E)-2-phosphonoethenyl]oxy}ethyl)amino}ethyl)phosphonic acid ChemComp-3L8: [(2-{[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](2-phosphonoethyl)amino}ethoxy)methyl]phosphonic acid
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE/TRANSFERASE INHIBITOR / Hypoxanthine-guanine phosphoribosyltransferase / Acyclic nucleoside monophosphonates / Malaria / 6-oxopurine phosphoribosyltransferase / 9-[(N-Phosphonoethyl-N-phosphonoethoxyethyl)-2-aminoethyl]-8-bromoguanine / cytoplasmic / TRANSFERASE-TRANSFERASE INHIBITOR complex / 9-[(N-Phosphonoethyl-N-phosphonomethoxyethyl)-2-aminoethyl]guanine / 9-[(N-Phosphonoethyl-N-phosphonoethoxyethyl)-2-aminoethyl]guanine / 9-[(N-(2-cyanoethyl)-N-(2-phosphonoethyl))-2-aminoethyl]-guanine / 9-[(N-Phosphonoethyl-N-phosphonoethoxyethyl)-2-aminoethyl]hypoxanthine / 9-[(N-Phosphonoethyl-N-phosphonomethoxyethyl)-2-aminoethyl]hypoxanthine