| タイトル | Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin |
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| ジャーナル・号・ページ | J. Med. Chem., Vol. 57, Page 8928-8935, Year 2014 |
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| 掲載日 | 2014年3月20日 (構造データの登録日) |
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著者 | Yokoyama, T. / Kosaka, Y. / Mizuguchi, M. |
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リンク | J. Med. Chem. / PubMed:25314129 |
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| 手法 | X線回折 |
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| 解像度 | 1.4 - 1.8 Å |
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| 構造データ | PDB-4pwe: Crystal structure of V30M mutant human transthyretin 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-4pwf: Crystal structure of V30M mutant human transthyretin complexed with ferulic acid phenethyl ester 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-4pwg: Crystal structure of V30M mutant human transthyretin complexed with caffeic acid ethyl ester 手法: X-RAY DIFFRACTION / 解像度: 1.798 Å PDB-4pwh: Crystal structure of V30M mutant human transthyretin complexed with caffeic acid 1,1-dimethylallyl ester 手法: X-RAY DIFFRACTION / 解像度: 1.798 Å PDB-4pwi: Crystal structure of V30M mutant human transthyretin complexed with rosmarinic acid 手法: X-RAY DIFFRACTION / 解像度: 1.494 Å PDB-4pwj: Crystal structure of V30M mutant human transthyretin complexed with nordihydroguaiaretic acid 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-4pwk: Crystal structure of V30M mutant human transthyretin complexed with dihydroguaiaretic acid 手法: X-RAY DIFFRACTION / 解像度: 1.59 Å PDB-4qrf: Crystal structure of V30M mutant human transthyretin complexed with caffeic acid phenethyl ester 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å |
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| 化合物 | ChemComp-PWF: 2-phenylethyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
ChemComp-0XR: ethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
ChemComp-PWH: 3-methylbut-2-en-1-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
ChemComp-ROA: (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid
ChemComp-30Z: 4-[(2R,3S)-3-[(3,4-DIHYDROXYPHENYL)METHYL]-2-METHYLBUTYL]BENZENE-1,2-DIOL
ChemComp-PWK: 4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol)
ChemComp-QAP: 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
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| 由来 | homo sapiens (ヒト)
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キーワード | TRANSPORT PROTEIN / Tranporter / thyroxine binding / transporter |
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