EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
ジャーナル・号・ページ	Plos One, Vol. 9, Page e109366-e109366, Year 2014
掲載日	2013年12月15日 (構造データの登録日)
著者	Wang, W. / Elkins, K. / Oh, A. / Ho, Y.C. / Wu, J. / Li, H. / Xiao, Y. / Kwong, M. / Coons, M. / Brillantes, B. ...Wang, W. / Elkins, K. / Oh, A. / Ho, Y.C. / Wu, J. / Li, H. / Xiao, Y. / Kwong, M. / Coons, M. / Brillantes, B. / Cheng, E. / Crocker, L. / Dragovich, P.S. / Sampath, D. / Zheng, X. / Bair, K.W. / O'Brien, T. / Belmont, L.D.
リンク	Plos One / PubMed:25285661
手法	X線回折
解像度	1.65 - 2.092 Å
構造データ	PDB-4o13: The crystal structure of NAMPT in complex with GNE-618 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-4o14: Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.871 Å PDB-4o15: The crystal structure of a mutant NAMPT (S165F) in complex with GNE-618 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4o16: Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.783 Å PDB-4o17: Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.82 Å PDB-4o18: Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-4o19: The crystal structure of a mutant NAMPT (G217V) 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-4o1a: The crystal structure of the mutant NAMPT G217R 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-4o1b: The crystal structure of a mutant NAMPT (G217R) in complex with an inhibitor APO866 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-4o1c: The crystal structures of a mutant NAMPT H191R 手法: X-RAY DIFFRACTION / 解像度: 2.092 Å PDB-4o1d: Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.705 Å PDB-4o28: Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2 Å
化合物	ChemComp-2P1: N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxamide ChemComp-PO4: PHOSPHATE ION / ホスファ-ト ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-HOH: WATER ChemComp-1XC: 6-({4-[(3,5-difluorophenyl)sulfonyl]benzyl}carbamoyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)imidazo[1,2-a]pyridin-1-ium ChemComp-DGB: (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide / FK-866 ChemComp-1QS: N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-6-carboxamide / N-[4-[(3,5-ジフルオロフェニル)スルホニル]ベンジル]イミダゾ[1,2-a]ピリジン-6-カルボアミド
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex / TRANSFERASE