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-Structure paper
タイトル | Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 57, Page 1708-1729, Year 2014 |
掲載日 | 2013年12月6日 (構造データの登録日) |
![]() | Scola, P.M. / Wang, A.X. / Good, A.C. / Sun, L.Q. / Combrink, K.D. / Campbell, J.A. / Chen, J. / Tu, Y. / Sin, N. / Venables, B.L. ...Scola, P.M. / Wang, A.X. / Good, A.C. / Sun, L.Q. / Combrink, K.D. / Campbell, J.A. / Chen, J. / Tu, Y. / Sin, N. / Venables, B.L. / Sit, S.Y. / Chen, Y. / Cocuzza, A. / Bilder, D.M. / D'Andrea, S. / Zheng, B. / Hewawasam, P. / Ding, M. / Thuring, J. / Li, J. / Hernandez, D. / Yu, F. / Falk, P. / Zhai, G. / Sheaffer, A.K. / Chen, C. / Lee, M.S. / Barry, D. / Knipe, J.O. / Li, W. / Han, Y.H. / Jenkins, S. / Gesenberg, C. / Gao, Q. / Sinz, M.W. / Santone, K.S. / Zvyaga, T. / Rajamani, R. / Klei, H.E. / Colonno, R.J. / Grasela, D.M. / Hughes, E. / Chien, C. / Adams, S. / Levesque, P.C. / Li, D. / Zhu, J. / Meanwell, N.A. / McPhee, F. |
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手法 | X線回折 |
解像度 | 1.62 - 2.2 Å |
構造データ | ![]() PDB-4nwk: ![]() PDB-4nwl: |
化合物 | ![]() ChemComp-2R8: ![]() ChemComp-ZN: ![]() ChemComp-SO4: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-2R9: |
由来 |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / SERINE PROTEASE / HYDROLASE-HYDROLASE INHIBITOR complex |