タイトル | Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 56, Page 9242-9250, Year 2013 |
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掲載日 | 2013年7月25日 (構造データの登録日) |
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著者 | Frank, A.O. / Feldkamp, M.D. / Kennedy, J.P. / Waterson, A.G. / Pelz, N.F. / Patrone, J.D. / Vangamudi, B. / Camper, D.V. / Rossanese, O.W. / Chazin, W.J. / Fesik, S.W. |
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リンク | J. Med. Chem. / PubMed:24147804 |
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手法 | X線回折 |
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解像度 | 1.2 - 1.9 Å |
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構造データ | PDB-4luo: Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions 手法: X-RAY DIFFRACTION / 解像度: 1.54 Å PDB-4luv: Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-4luz: Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-4lw1: Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions 手法: X-RAY DIFFRACTION / 解像度: 1.631 Å PDB-4lwc: Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions 手法: X-RAY DIFFRACTION / 解像度: 1.61 Å PDB-4o0a: Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å |
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化合物 | ChemComp-1DZ: 1-(3-methylphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid
ChemComp-1XS: 5-(3-chloro-4-fluorophenyl)furan-2-carboxylic acid
ChemComp-1XT: 5-(4-{[4-(5-carboxyfuran-2-yl)benzyl]oxy}phenyl)-1-(3-methylphenyl)-1H-pyrazole-3-carboxylic acid
ChemComp-1XU: 5-[3-chloro-4-({4-[1-(3,4-dichlorophenyl)-1H-pyrazol-5-yl]benzyl}carbamothioyl)phenyl]furan-2-carboxylic acid
ChemComp-2P9: 5-{4-[({[4-(5-carboxyfuran-2-yl)-2-chlorophenyl]carbonothioyl}amino)methyl]phenyl}-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
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由来 | homo sapiens (ヒト)
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キーワード | PROTEIN BINDING / OB-FOLD / PROTEIN-PROTEIN INTERACTION / DNA BINDING protein/inhibitor / DNA BINDING protein-inhibitor complex |
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