EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery of Tankyrase Inhibiting Flavones with Increased Potency and Isoenzyme Selectivity.
ジャーナル・号・ページ	J. Med. Chem., Vol. 56, Page 7880-, Year 2013
掲載日	2013年6月7日 (構造データの登録日)
著者	Narwal, M. / Koivunen, J. / Haikarainen, T. / Obaji, E. / Legala, O.E. / Venkannagari, H. / Joensuu, P. / Pihlajaniemi, T. / Lehtio, L.
リンク	J. Med. Chem. / PubMed:24116873
手法	X線回折
解像度	1.7 - 2.3 Å
構造データ	PDB-4bs4: Crystal structure of human tankyrase 2 in complex with 4'-isopropylflavone 手法: X-RAY DIFFRACTION / 解像度: 1.89 Å PDB-4kzl: Crystal structure of human tankyrase 2 in complex with 4'-fluoro flavone 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4kzq: Crystal structure of human tankyrase 2 in complex with 4' -hydroxy flavone 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-4kzu: Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4l09: Crystal structure of human tankyrase 2 in complex with 4-(4-oxo-4H-chromen-2-yl)benzoic acid 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-4l0b: Tankyrase 2 in complex with 4'-dimethylamino flavone 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4l0i: Tankyrase 2 catalytic domain in complex with ethyl 4-(4-oxo-4H-chromen-2-yl)benzoate 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-4l0s: Tankyrase 2 in complex with 4'-cyano flavone 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-4l0t: Tankyrase 2 in complex with 4'-nitro flavone 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4l0v: Tankyrase 2 in complex with 4'-chloro flavone 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4l10: Tankyrase 2 in complex with 4'-methoxy flavone 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4l2f: Tankyrase 2 in complex with 6-chloro flavone 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-4l2g: Tankyrase 2 in complex with 6- fluoro flavone 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-4l2k: Tankyrase 2 in complex with 2-(1,3-benzodioxol-5-yl)-4H-chromen-4-one 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4l31: Tankyrase 2 in complex with methyl 4-(4-oxochromen-2-yl)benzoate 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4l32: Tankyrase 2 in complex with 2-[4-(4-methylpiperazine-1-carbonyl)phenyl]chromen-4-one 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-4l33: Tankyrase 2 in complex with cyanomethyl 4-(4-oxo-4H-chromen-2-yl)benzoate 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4l34: Tankyrase 2 in complex with 4'-tetrazole flavone 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-A64: 4'-ISOPROPYLFLAVONE / 2-(4-イソプロピルフェニル)-4H-1-ベンゾピラン-4-オン ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-PEG: DI(HYDROXYETHYL)ETHER / ジエチレングリコ-ル ChemComp-HOH: WATER ChemComp-20D: 2-(4-fluorophenyl)-4H-chromen-4-one / 2-(4-フルオロフェニル)-4H-1-ベンゾピラン-4-オン ChemComp-DFL: 2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE / (S)-2α-(4-ヒドロキシフェニル)-2,3-ジヒドロ-4H-1-ベンゾピラン-4-オン ChemComp-A73: 2-(4-bromophenyl)-4H-chromen-4-one / 4′-ブロモフラボン ChemComp-1UR: 4-(4-oxo-4H-chromen-2-yl)benzoic acid / 4-(クロモン-2-イル)安息香酸 ChemComp-1UT: 2-[4-(dimethylamino)phenyl]-4H-chromen-4-one / 2-[4-(ジメチルアミノ)フェニル]-4H-1-ベンゾピラン-4-オン ChemComp-1UW: ethyl 4-(4-oxo-4H-chromen-2-yl)benzoate ChemComp-1UZ: 4-(4-oxo-4H-chromen-2-yl)benzonitrile / 4′-シアノフラボン ChemComp-1V0: 2-(4-nitrophenyl)-4H-chromen-4-one ChemComp-1V1: 2-(4-chlorophenyl)-4H-chromen-4-one / 4′-クロロフラボン ChemComp-A63: 2-(4-methoxyphenyl)-4H-chromen-4-one / 4′-メトキシフラボン ChemComp-1V3: 6-chloro-2-phenyl-4H-chromen-4-one / 2-フェニル-6-クロロ-4H-1-ベンゾピラン-4-オン ChemComp-1V4: 6-fluoro-2-phenyl-4H-chromen-4-one / 2-フェニル-6-フルオロ-4H-1-ベンゾピラン-4-オン ChemComp-1V8: 2-(1,3-benzodioxol-5-yl)-4H-chromen-4-one / 2-(1,3-ベンゾジオキソ-ル-5-イル)-4H-1-ベンゾピラン-4-オン ChemComp-F08: methyl 4-(4-oxo-4H-chromen-2-yl)benzoate ChemComp-1VF: 2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-4H-chromen-4-one ChemComp-F70: cyanomethyl 4-(4-oxo-4H-chromen-2-yl)benzoate ChemComp-1VG: 2-[4-(1H-tetrazol-5-yl)phenyl]-4H-chromen-4-one
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / PROTEIN-LIGAND COMPLEX / DIPHTHERIA TOXIN LIKE FOLD / ADP- RIBOSYLATION / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX / TRANSFERASE/TRANSFERASE INHIBITOR / ADP-RIBOSYLATION