タイトル | Dissecting Cytochrome P450 3A4-Ligand Interactions Using Ritonavir Analogues. |
---|
ジャーナル・号・ページ | Biochemistry, Vol. 52, Page 4474-4481, Year 2013 |
---|
掲載日 | 2013年4月21日 (構造データの登録日) |
---|
著者 | Sevrioukova, I.F. / Poulos, T.L. |
---|
リンク | Biochemistry / PubMed:23746300 |
---|
手法 | X線回折 |
---|
解像度 | 2.399 - 2.85 Å |
---|
構造データ | PDB-4k9t: Complex of CYP3A4 with a desoxyritonavir analog 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-4k9u: Complex of human CYP3A4 with a desoxyritonavir analog 手法: X-RAY DIFFRACTION / 解像度: 2.85 Å PDB-4k9v: Complex of CYP3A4 with a desoxyritonavir analog 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-4k9w: Complex of human CYP3A4 with a desoxyritonavir analog 手法: X-RAY DIFFRACTION / 解像度: 2.399 Å PDB-4k9x: Complex of human CYP3A4 with a desoxyritonavir analog 手法: X-RAY DIFFRACTION / 解像度: 2.76 Å |
---|
化合物 | ChemComp-1RD: N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-N-(4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}butyl)-L-valinamide
ChemComp-5AW: N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-N-[(2S,5S)-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-D-valinamide
ChemComp-6AW: 1,3-thiazol-5-ylmethyl [(3S,6S)-6-{[N-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-seryl]amino}octan-3-yl]carbamate
ChemComp-7AW: N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-N-[(2R,5S)-1-phenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}octan-2-yl]-L-valinamide
ChemComp-8AW: 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-methylbutanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate
|
---|
由来 | homo sapiens (ヒト)
|
---|
キーワード | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / cytochrome P450 3A4 / alpha-beta protein / cytochrome P450 fold / monooxygenase / cytochrome P450 reductase / endoplasmic reticulum / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |
---|