EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
ジャーナル・号・ページ	Bioorg. Med. Chem. Lett., Vol. 23, Page 5674-5679, Year 2013
掲載日	2013年4月14日 (構造データの登録日)
著者	Jing, Q. / Li, H. / Chreifi, G. / Roman, L.J. / Martasek, P. / Poulos, T.L. / Silverman, R.B.
リンク	Bioorg. Med. Chem. Lett. / PubMed:23993333
手法	X線回折
解像度	1.85 - 2.36 Å
構造データ	PDB-4k5d: Structure of neuronal nitric oxide synthase heme domain in complex with (S)-1,2-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-propan-3-amine 手法: X-RAY DIFFRACTION / 解像度: 2.096 Å PDB-4k5e: Structure of neuronal nitric oxide synthase heme domain in complex with (R)-1,2-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-propan-3-amine 手法: X-RAY DIFFRACTION / 解像度: 1.892 Å PDB-4k5f: Structure of neuronal nitric oxide synthase heme domain in complex with (S)-1,3-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-butan-4-amine 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4k5g: Structure of neuronal nitric oxide synthase heme domain in complex with ((2S, 3S)-1,3-bis((6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)methoxy)-2-aminobutane 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-4k5h: Structure of bovine endothelial nitric oxide synthase heme domain in complex with (S)-1,2-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-propan-3-amine 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-4k5i: Structure of bovine endothelial nitric oxide synthase heme domain in complex with (R)-1,2-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-propan-3-amine 手法: X-RAY DIFFRACTION / 解像度: 2.08 Å PDB-4k5j: Structure of bovine endothelial nitric oxide synthase heme domain in complex with (S)-1,3-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-butan-4-amine 手法: X-RAY DIFFRACTION / 解像度: 2.36 Å PDB-4k5k: Structure of bovine endothelial nitric oxide synthase heme domain in complex with ((2S, 3S)-1,3-bis((6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)methoxy)-2-aminobutane 手法: X-RAY DIFFRACTION / 解像度: 2 Å
化合物	ChemComp-HEM: PROTOPORPHYRIN IX CONTAINING FE ChemComp-H4B: 5,6,7,8-TETRAHYDROBIOPTERIN / 6R-テトラヒドロビオプテリン / 神経伝達物質YM ChemComp-ACT: ACETATE ION / 酢酸イオン ChemComp-1Q6: 6,6'-{[(2S)-3-aminopropane-1,2-diyl]bis(oxymethanediyl)}bis(4-methylpyridin-2-amine) ChemComp-ZN: Unknown entry ChemComp-HOH: WATER ChemComp-1Q7: 6,6'-{[(2R)-3-aminopropane-1,2-diyl]bis(oxymethanediyl)}bis(4-methylpyridin-2-amine) ChemComp-Q14: 6-[({(2S)-1-amino-4-[(6-amino-4-methylpyridin-2-yl)methoxy]butan-2-yl}oxy)methyl]-4-methylpyridin-2-amine ChemComp-Q13: 6,6'-{[(2S,3S)-2-aminobutane-1,3-diyl]bis(oxymethanediyl)}bis(4-methylpyridin-2-amine) / (3S,4S)-1,7-ビス(4-メチル-6-アミノピリジン-2-イル)-3-メチル-4-アミノ-2,6-ジオキサヘプ(以下略) ChemComp-GOL*: GLYCEROL / グリセロ-ル
由来	rattus norvegicus (ドブネズミ) bos taurus (ウシ)
キーワード	OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / nitric oxide synthase / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex