タイトル | A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. |
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ジャーナル・号・ページ | Nat. Struct. Mol. Biol., Vol. 20, Page 728-734, Year 2013 |
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掲載日 | 2013年3月9日 (構造データの登録日) |
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著者 | Schellenberg, M.J. / Wu, T. / Ritchie, D.B. / Fica, S. / Staley, J.P. / Atta, K.A. / Lapointe, P. / Macmillan, A.M. |
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リンク | Nat. Struct. Mol. Biol. / PubMed:23686287 |
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手法 | X線回折 |
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解像度 | 1.15 - 1.95 Å |
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構造データ | PDB-4jk7: Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Mg ion 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-4jk8: Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Mg ion 手法: X-RAY DIFFRACTION / 解像度: 1.15 Å PDB-4jk9: Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Co ion 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-4jka: Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Co ion 手法: X-RAY DIFFRACTION / 解像度: 1.32 Å PDB-4jkb: Open and closed forms of V1788D human PRP8 RNase H-like domain with bound Mg ion 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-4jkc: Open and closed forms of T1800E human PRP8 RNase H-like domain with bound Mg ion 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-4jkd: Open and closed forms of I1790Y human PRP8 RNase H-like domain with bound Mg ion 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-4jke: Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-4jkf: Open and closed forms of T1791P+R1865A human PRP8 RNase H-like domain with bound Mg ion 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-4jkg: Open and closed forms of mixed T1789P+R1865A and R1865A human PRP8 RNase H-like domain with bound Mg ion 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4jkh: Open and closed forms of D1781E human PRP8 RNase H-like domain with bound Mg ion 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å |
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化合物 | |
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由来 | - homo sapiens (ヒト)
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キーワード | RNA BINDING PROTEIN (RNA結合タンパク質) / metalloprotein (金属タンパク質) / conformational change (コンフォメーション変化) |
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