タイトル | New thymine derivatives as HSV1-TK ligand for the development of PET imaging tracer |
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ジャーナル・号・ページ | To be Published |
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掲載日 | 2013年1月23日 (構造データの登録日) |
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著者 | Pernot, L. / Novakovic, I. / Perozzo, R. / Raic-Malic, S. / Scapozza, L. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.9 - 2.4 Å |
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構造データ | PDB-4ivp: Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with IN51/20 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4ivq: Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with IN43/5 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-4ivr: Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with IN52/10 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-4jbx: Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with SK-78 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4jby: Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with F-SK78 手法: X-RAY DIFFRACTION / 解像度: 2 Å |
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化合物 | ChemComp-I51: 6-[3-hydroxy-2-(hydroxymethyl)prop-1-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
ChemComp-I43: 6-[3-hydroxy-2-(hydroxymethyl)prop-1-en-1-yl]-4-methoxy-1,5-dimethylpyrimidin-2(1H)-one
ChemComp-N50: 2-[(2,6-dimethoxy-5-methylpyrimidin-4-yl)methylidene]propane-1,3-diol
ChemComp-SK7: 6-[3-hydroxy-2-(hydroxymethyl)prop-1-en-1-yl]-1,5-dimethylpyrimidine-2,4(1H,3H)-dione
ChemComp-FSK: 6-[(1Z)-3-fluoro-2-(hydroxymethyl)prop-1-en-1-yl]-1,5-dimethylpyrimidine-2,4(1H,3H)-dione
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由来 | ![](img/tx_virus.gif) human herpesvirus 1 (ヘルペスウイルス)
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キーワード | TRANSFERASE / DNA synthesis / PET imaging TRACER / ATP binding / nucleotide binding |
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