タイトル | Crystal structure and mechanism of activation of TANK-binding kinase 1. |
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ジャーナル・号・ページ | Cell Rep, Vol. 3, Page 734-746, Year 2013 |
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掲載日 | 2013年1月23日 (構造データの登録日) |
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著者 | Larabi, A. / Devos, J.M. / Ng, S.L. / Nanao, M.H. / Round, A. / Maniatis, T. / Panne, D. |
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リンク | Cell Rep / PubMed:23453971 |
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手法 | X線回折 |
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解像度 | 2.61 - 4 Å |
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構造データ | PDB-4iw0: Crystal structure and mechanism of activation of TBK1 手法: X-RAY DIFFRACTION / 解像度: 4 Å PDB-4iwo: Crystal structure and mechanism of activation of TBK1 手法: X-RAY DIFFRACTION / 解像度: 2.61 Å PDB-4iwp: Crystal structure and mechanism of activation of TBK1 手法: X-RAY DIFFRACTION / 解像度: 3.065 Å PDB-4iwq: Crystal structure and mechanism of activation of TBK1 手法: X-RAY DIFFRACTION / 解像度: 3 Å |
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化合物 | ChemComp-BX7: N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide
ChemComp-1H4: N-{3-[(5-cyclopropyl-2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide
ChemComp-1FV: N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / KINASE / ATP binding / Phosphorylation / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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