EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.
ジャーナル・号・ページ	J. Med. Chem., Vol. 56, Page 2738-2746, Year 2013
掲載日	2012年12月10日 (構造データの登録日)
著者	Bauman, J.D. / Patel, D. / Dharia, C. / Fromer, M.W. / Ahmed, S. / Frenkel, Y. / Vijayan, R.S. / Eck, J.T. / Ho, W.C. / Das, K. ...Bauman, J.D. / Patel, D. / Dharia, C. / Fromer, M.W. / Ahmed, S. / Frenkel, Y. / Vijayan, R.S. / Eck, J.T. / Ho, W.C. / Das, K. / Shatkin, A.J. / Arnold, E.
リンク	J. Med. Chem. / PubMed:23342998
手法	X線回折
解像度	1.8 - 2.5 Å
構造データ	PDB-4icl: HIV-1 reverse transcriptase with bound fragment at the incoming dNTP binding site 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4id5: HIV-1 reverse transcriptase with bound fragment at the RNase H primer grip site 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-4idk: HIV-1 reverse transcriptase with bound fragment at the 428 site 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4ifv: Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-Ray Crystallographic Fragment Screening 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-4ify: HIV-1 reverse transcriptase with bound fragment at the Knuckles site 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4ig0: HIV-1 reverse transcriptase with bound fragment at the 507 site 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-4ig3: HIV-1 reverse transcriptase with bound fragment near Knuckles site 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-4kfb: HIV-1 reverse transcriptase with bound fragment at NNRTI adjacent site 手法: X-RAY DIFFRACTION / 解像度: 1.854 Å
化合物	ChemComp-T27: 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile / 薬剤YM ChemComp-MG: Unknown entry ChemComp-DMS: DIMETHYL SULFOXIDE / DMSO, 沈殿剤YM ChemComp-14N: 4-(4-methylpiperazin-1-yl)benzoic acid ChemComp-HOH: WATER ChemComp-1FF: 1-methyl-5-phenyl-1H-pyrazole-4-carboxylic acid ChemComp-1FE: N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)glycinamide ChemComp-FMQ: [1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl]methanol ChemComp-1FD: 1-[4-(trifluoromethoxy)phenyl]methanamine ChemComp-1FG: 2-({[2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl](methyl)amino}methyl)quinazolin-4(1H)-one ChemComp-J94: (5S)-6,6-dimethyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium ChemComp-1QP: ethyl pyrazolo[1,5-a]pyridine-3-carboxylate
由来	human immunodeficiency virus type 1 (ヒト免疫不全ウイルス) human immunodeficiency virus type 1 bh10 (ヒト免疫不全ウイルス)
キーワード	transferase/transferase inhibitor / RNA-DIRECTED DNA POLYMERASE / DNA POLYMERASE / ENDONUCLEASE / HYDROLASE / MULTIFUNCTIONAL ENZYME / transferase-transferase inhibitor complex / HYDROLASE-INHIBITOR COMPLEX