タイトル | Two-armed benzopurine inhibitors of TGT |
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ジャーナル・号・ページ | To be Published |
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掲載日 | 2012年8月6日 (構造データの登録日) |
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著者 | Immekus, F. / Barandun, L.J. / Diederich, F. / Klebe, G. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.45 - 2.06 Å |
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構造データ | PDB-4gg9: tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanthine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.48 Å PDB-4gh1: tRNA Guanine Transglycosylase in complex with morpholine substituted lin-benzohypoxanthine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-4gh3: tRNA Guanine Transglycosylase in complex with phenethyl substituted lin-benzohypoxanthine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å PDB-4gi4: tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.97 Å PDB-4giy: tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-4gkt: tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.53 Å |
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化合物 | ChemComp-0WW: 4-{2-[(cyclohexylmethyl)amino]ethyl}-2-[(thiophen-2-ylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
ChemComp-0WX: 4-{2-[(cyclohexylmethyl)amino]ethyl}-2-{[2-(morpholin-4-yl)ethyl]amino}-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
ChemComp-0EV: 4-{2-[(cyclohexylmethyl)amino]ethyl}-2-[(2-phenylethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
ChemComp-0EX: 6-amino-4-[2-(benzylamino)ethyl]-2-[(2-phenylethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
ChemComp-0WY: 6-amino-4-{2-[(cyclohexylmethyl)amino]ethyl}-2-[(2-phenylethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
ChemComp-0O1: 6-amino-4-{2-[(cyclopentylmethyl)amino]ethyl}-2-[(2-phenylethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
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由来 | zymomonas mobilis subsp. mobilis (バクテリア)
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キーワード | TRANSFERASE/TRANSFERASE inhibitor / TIM BARREL / GLYCOSYLTRANSFERASE / QUEUOSINE / BIOSYNTHESIS / TRNA PROCESSING / TRANSFERASE-TRANSFERASE inhibitor complex / TRNA / TIM BARREL GLYCOSYLTRANSFERASE |
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