タイトル | Studies on TGT homodimer interface |
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ジャーナル・号・ページ | To be Published |
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掲載日 | 2012年6月22日 (構造データの登録日) |
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著者 | Immekus, F. / Barandun, L.J. / Betz, M. / Debaene, F. / Petiot, S. / Sanglier-Cianferani, S. / Diederich, F. / Klebe, G. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.45 - 1.74 Å |
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構造データ | PDB-4fps: tRNA-Guanine Transglycosylase in complex with adamantyl-substituted lin-benzoguanine ligand 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-4fr1: tRNA-Guanine Transglycosylase cocrystallized with alkine-substituted lin-benzoguanine ligand 手法: X-RAY DIFFRACTION / 解像度: 1.74 Å PDB-4fr6: tRNA-Guanine Transglycosylase cocrystallized with pyridyl-alkine-substituted lin-benzoguanine ligand 手法: X-RAY DIFFRACTION / 解像度: 1.59 Å PDB-4fsa: tRNA-Guanine Transglycosylase soaked with pyridyl-alkine-substituted lin-benzoguanine ligand 手法: X-RAY DIFFRACTION / 解像度: 1.62 Å |
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化合物 | ChemComp-0UX: 6-amino-2-(methylamino)-4-(2-{[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-ylmethyl]amino}ethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
ChemComp-0V2: 6-amino-4-[2-({[trans-4-(biphenyl-4-ylethynyl)cyclohexyl]methyl}amino)ethyl]-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
ChemComp-0V3: 6-amino-2-(methylamino)-4-[2-({[trans-4-(pyridin-3-ylethynyl)cyclohexyl]methyl}amino)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
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由来 | - zymomonas mobilis subsp. mobilis (バクテリア)
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キーワード | TRANSFERASE/TRANSFERASE inhibitor / TIM BARREL / GLYCOSYLTRANSFERASE / QUEUOSINE / BIOSYNTHESIS / TRANSFERASE / TRNA PROCESSING / TRNA / TRANSFERASE-TRANSFERASE inhibitor complex |
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