タイトル | Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme. |
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ジャーナル・号・ページ | Nucleic Acids Res., Vol. 40, Page 9308-9318, Year 2012 |
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掲載日 | 2012年6月6日 (構造データの登録日) |
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著者 | Benjdia, A. / Heil, K. / Barends, T.R. / Carell, T. / Schlichting, I. |
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リンク | Nucleic Acids Res. / PubMed:22761404 |
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手法 | X線回折 |
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解像度 | 2 - 2.3 Å |
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構造データ | PDB-4fhc: Spore photoproduct lyase 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4fhd: Spore photoproduct lyase complexed with dinucleoside spore photoproduct 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4fhe: Spore photoproduct lyase C140A mutant 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4fhf: Spore photoproduct lyase C140A mutant with dinucleoside spore photoproduct 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-4fhg: Spore photoproduct lyase C140S mutant 手法: X-RAY DIFFRACTION / 解像度: 2 Å |
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化合物 | ChemComp-EEM: [(3S)-3-amino-4-hydroxy-4-oxo-butyl]-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl]-methyl-selanium
ChemComp-0TT: 1-[(2R,4S,5R)-5-(hydroxymethyl)-4-oxidanyl-oxolan-2-yl]-5-[[(5R)-1-[(2R,4S,5R)-5-(hydroxymethyl)-4-oxidanyl-oxolan-2-yl]-5-methyl-2,4-bis(oxidanylidene)-1,3-diazinan-5-yl]methyl]pyrimidine-2,4-dione / (5R)-5-(チミジン-α-イル)-5,6-ジヒドロチミジン
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由来 | geobacillus thermodenitrificans (バクテリア)
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キーワード | LYASE / partial TIM-barrel / DNA repair / damaged DNA |
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