タイトル | An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. |
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ジャーナル・号・ページ | Chem. Biol., Vol. 19, Page 1028-1040, Year 2012 |
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掲載日 | 2012年4月14日 (構造データの登録日) |
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著者 | Echalier, A. / Cot, E. / Camasses, A. / Hodimont, E. / Hoh, F. / Jay, P. / Sheinerman, F. / Krasinska, L. / Fisher, D. |
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リンク | Chem. Biol. / PubMed:22921070 |
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手法 | X線回折 |
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解像度 | 1.65 - 2.57 Å |
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構造データ | PDB-4eoi: Thr 160 phosphorylated CDK2 K89D, Q131E - human cyclin A3 complex with the inhibitor RO3306 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-4eoj: Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with ATP 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-4eok: Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102 手法: X-RAY DIFFRACTION / 解像度: 2.57 Å PDB-4eol: Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor RO3306 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-4eom: Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with ATP 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4eon: Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with the inhibitor RO3306 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-4eoo: Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with ATP 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4eop: Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with the inhibitor RO3306 手法: X-RAY DIFFRACTION / 解像度: 1.99 Å PDB-4eoq: Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with ATP 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-4eor: Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor NU6102 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4eos: Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor RO3306 手法: X-RAY DIFFRACTION / 解像度: 2.57 Å |
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化合物 | ChemComp-1RO: (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one / RO-3306
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / protein kinase / cell cycle / phosphorylation / TRANSFERASE-TRANSFERASE INHIBITOR complex / TRANSFERASE / COMPLEX |
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