| タイトル | Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease. |
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| ジャーナル・号・ページ | Plos Pathog., Vol. 8, Page e1002830-e1002830, Year 2012 |
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| 掲載日 | 2012年3月14日 (構造データの登録日) |
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著者 | Dubois, R.M. / Slavish, P.J. / Baughman, B.M. / Yun, M.K. / Bao, J. / Webby, R.J. / Webb, T.R. / White, S.W. |
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リンク | Plos Pathog. / PubMed:22876176 |
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| 手法 | X線回折 |
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| 解像度 | 2.048 - 2.944 Å |
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| 構造データ | PDB-4e5e: Crystal structure of avian influenza virus PAn Apo 手法: X-RAY DIFFRACTION / 解像度: 2.048 Å PDB-4e5f: Crystal structure of avian influenza virus PAn bound to compound 1 手法: X-RAY DIFFRACTION / 解像度: 2.392 Å PDB-4e5g: Crystal structure of avian influenza virus PAn bound to compound 2 手法: X-RAY DIFFRACTION / 解像度: 2.647 Å PDB-4e5h: Crystal structure of avian influenza virus PAn bound to compound 3 手法: X-RAY DIFFRACTION / 解像度: 2.158 Å PDB-4e5i: Crystal structure of avian influenza virus PAn bound to compound 4 手法: X-RAY DIFFRACTION / 解像度: 2.944 Å PDB-4e5j: Crystal structure of avian influenza virus PAn bound to compound 5 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-4e5l: Crystal structure of avian influenza virus PAn bound to compound 6 手法: X-RAY DIFFRACTION / 解像度: 2.469 Å |
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| 化合物 | ChemComp-0N8: (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid
ChemComp-0N9: 5-hydroxy-2-(1-methyl-1H-imidazol-4-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid
ChemComp-581: 2-[3-(acetylamino)phenyl]-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid
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| 由来 |  influenza a virus (A型インフルエンザウイルス)
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キーワード | VIRAL PROTEIN / TRANSCRIPTION / endonuclease domain / H5N1 subtype |
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