EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib.
ジャーナル・号・ページ	J. Med. Chem., Vol. 57, Page 1170-, Year 2014
掲載日	2011年4月8日 (構造データの登録日)
著者	Huang, Q. / Johnson, T.W. / Bailey, S. / Brooun, A. / Bunker, K.D. / Burke, B.J. / Collins, M.R. / Cook, A.S. / Cui, J.J. / Dack, K.N. ...Huang, Q. / Johnson, T.W. / Bailey, S. / Brooun, A. / Bunker, K.D. / Burke, B.J. / Collins, M.R. / Cook, A.S. / Cui, J.J. / Dack, K.N. / Deal, J.G. / Deng, Y. / Dinh, D. / Engstrom, L.D. / He, M. / Hoffman, J. / Hoffman, R.L. / Johnson, P.S. / Kania, R.S. / Lam, H. / Lam, J.L. / Le, P.T. / Li, Q. / Lingardo, L. / Liu, W. / Lu, M.W. / Mctigue, M. / Palmer, C.L. / Richardson, P.F. / Sach, N.W. / Shen, H. / Smeal, T. / Smith, G.L. / Stewart, A.E. / Timofeevski, S. / Tsaparikos, K. / Wang, H. / Zhu, H. / Zhu, J. / Zou, H.Y. / Edwards, M.P.
リンク	J. Med. Chem. / PubMed:24432909
手法	X線回折
解像度	1.7 - 2.23 Å
構造データ	PDB-2yfx: Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-2yhv: Structure of L1196M Mutant Anaplastic Lymphoma Kinase 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-4anl: Structure of G1269A Mutant Anaplastic Lymphoma Kinase 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4anq: Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib 手法: X-RAY DIFFRACTION / 解像度: 1.76 Å PDB-4ccb: Structure of the Human Anaplastic Lymphoma Kinase in Complex with 3-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)-5-(5-methyl-1H- pyrazol-4-yl)pyridin-2-amine 手法: X-RAY DIFFRACTION / 解像度: 2.03 Å PDB-4ccu: Structure of the Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy) pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-4cd0: Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2- yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propane-1,2-diol 手法: X-RAY DIFFRACTION / 解像度: 2.23 Å
化合物	ChemComp-VGH: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine / クリゾチニブ / 薬剤, 抗がん剤YM ChemComp-HOH: WATER ChemComp-OFG: 3-[(1R)-1-[5-fluoranyl-2-(1,2,3-triazol-2-yl)phenyl]ethoxy]-5-(3-methyl-1H-pyrazol-4-yl)pyridin-2-amine ChemComp-AWF: 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol / 2-[5-[6-アミノ-5-[(1R)-1-[5-フルオロ-2-(2H-1,2,3-トリアゾ-ル-2-イル)フェニル](以下略) ChemComp-AWJ*: (2R)-2-[5-(6-amino-5-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / NUCLEOTIDE-BINDING / RECEPTOR / CRIZOTINIB / RECEPTOR TYROSINE KINASE / ANAPLASTIC LYMPHOMA KINASE / INHIBITOR