EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Simplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition.
ジャーナル・号・ページ	J. Med. Chem., Vol. 57, Page 1513-, Year 2014
掲載日	2013年10月8日 (構造データの登録日)
著者	Cinelli, M.A. / Li, H. / Chreifi, G. / Martasek, P. / Roman, L.J. / Poulos, T.L. / Silverman, R.B.
リンク	J. Med. Chem. / PubMed:24472039
手法	X線回折
解像度	1.79 - 2.06 Å
構造データ	PDB-4cam: Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-((3-Fluorophenethylamino)methyl)quinolin-2-amine 手法: X-RAY DIFFRACTION / 解像度: 1.83 Å PDB-4can: Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(2-(3-Fluorobenzylamino)ethyl)quinolin-2-amine 手法: X-RAY DIFFRACTION / 解像度: 1.91 Å PDB-4cao: Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(2-(3-(3-Fluorophenyl(propylamino)ethyl))quinolin-2- amine 手法: X-RAY DIFFRACTION / 解像度: 1.98 Å PDB-4cap: Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(2-(3-(3-Fluorophenyl(propylamino)methyl))quinolin-2- amine 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å PDB-4caq: Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-((3-Chlorophenethylamino)ethyl)quinolin-2-amine 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-4car: Structure of bovine endothelial nitric oxide synthase heme domain in complex with 7-((3-Fluorophenethylamino)methyl)quinolin-2-amine 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-4cdt: Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-((3-Fluorophenethylamino)ethyl)quinolin-2-amine 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4cft: Structure of bovine endothelial nitric oxide synthase heme domain in complex with 7-((3-Fluorophenethylamino)ethyl)quinolin-2-amine 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å
化合物	ChemComp-HEM: PROTOPORPHYRIN IX CONTAINING FE / Heme B ChemComp-H4B: 5,6,7,8-TETRAHYDROBIOPTERIN / 6R-テトラヒドロビオプテリン / 神経伝達物質YM / テトラヒドロビオプテリン ChemComp-M87: 7-[[2-(3-fluorophenyl)ethylamino]methyl]quinolin-2-amine ChemComp-ACT: ACETATE ION / 酢酸イオン / 酢酸塩 ChemComp-ZN: Unknown entry ChemComp-HOH: WATER / 水 ChemComp-M7K: 7-{2-[(3-fluorobenzyl)amino]ethyl}quinolin-2-amine ChemComp-M46: 7-[2-[3-(3-fluorophenyl)propylamino]ethyl]quinolin-2-amine ChemComp-ML6: 7-({[3-(3-fluorophenyl)propyl]amino}methyl)quinolin-2-amine ChemComp-M68: 7-[2-[2-(3-chlorophenyl)ethylamino]ethyl]quinolin-2-amine / 7-[2-[(3-クロロフェネチル)アミノ]エチル]キノリン-2-アミン ChemComp-GOL: GLYCEROL / グリセロ-ル / グリセリン ChemComp-M48*: 7-[2-[2-(3-fluorophenyl)ethylamino]ethyl]quinolin-2-amine / 7-[2-[(3-フルオロフェネチル)アミノ]エチル]キノリン-2-アミン
由来	rattus norvegicus (ドブネズミ) bos taurus (ウシ)
キーワード	OXIDOREDUCTASE (酸化還元酵素) / INHIBITOR COMPLEX (酵素阻害剤) / NITRIC OXIDE SYNTHASE (一酸化窒素合成酵素)