タイトル | Crystal Structures of Highly Specific Phosphinic Tripeptide Enantiomers in Complex with the Angiotensin-I Converting Enzyme. |
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ジャーナル・号・ページ | FEBS J., Vol. 281, Page 943-, Year 2014 |
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掲載日 | 2013年10月7日 (構造データの登録日) |
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著者 | Masuyer, G. / Akif, M. / Czarny, B. / Beau, F. / Schwager, S.L. / Sturrock, E.D. / Isaac, R.E. / Dive, V. / Acharya, K.R. |
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リンク | FEBS J. / PubMed:24289879 |
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手法 | X線回折 |
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解像度 | 1.82 - 1.99 Å |
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構造データ | PDB-4ca5: Human Angiotensin converting enzyme in complex with a phosphinic tripeptide FI 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-4ca6: Human Angiotensin converting enzyme N-domain in complex with a phosphinic tripeptide FI 手法: X-RAY DIFFRACTION / 解像度: 1.91 Å PDB-4ca7: Drosophila Angiotensin converting enzyme (AnCE) in complex with a phosphinic tripeptide FI 手法: X-RAY DIFFRACTION / 解像度: 1.82 Å PDB-4ca8: Drosophila Angiotensin converting enzyme (AnCE) in complex with a phosphinic tripeptide FII 手法: X-RAY DIFFRACTION / 解像度: 1.99 Å |
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化合物 | ChemComp-3EF: N-{(2S)-3-[(S)-[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]-2-[(3-phenyl-1,2-oxazol-5-yl)methyl]propanoyl}-L-tyrosine
ChemComp-3ES: [(2S)-2-({3-[HYDROXYL(2-PHENYL-(1R)-1-{[(BENZYLOXY)[(2S)-2-({3-[HYDROXYL(2-PHENYL-(1R)-1-CARBONYL]-AMINO}ETHYL)PHOSPHINYL]-2-[(3-PHENYLISOXAZOL-5-YL)METHYL]-1-OXO-PROPYL}AMINO)-3-(4-HYDROXY-PHENYL)
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由来 | ![](img/tx_human.gif) homo sapiens (ヒト)![](img/tx_arthropod.gif) ![](data/taxo/icon/Drosophila_melanogaster_S.png) drosophila melanogaster (キイロショウジョウバエ)
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キーワード | HYDROLASE (加水分解酵素) / ZINC METALLOPEPTIDASE / INHIBITOR BINDING (酵素阻害剤) |
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