タイトル | Naphthyridines as Novel Bet Family Bromodomain Inhibitors. |
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ジャーナル・号・ページ | Chemmedchem, Vol. 9, Page 589-, Year 2014 |
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掲載日 | 2013年6月29日 (構造データの登録日) |
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著者 | Mirguet, O. / Lamotte, Y. / Chung, C. / Bamborough, P. / Delannee, D. / Bouillot, A. / Gellibert, F. / Krysa, G. / Lewis, A. / Witherington, J. ...Mirguet, O. / Lamotte, Y. / Chung, C. / Bamborough, P. / Delannee, D. / Bouillot, A. / Gellibert, F. / Krysa, G. / Lewis, A. / Witherington, J. / Huet, P. / Dudit, Y. / Trottet, L. / Nicodeme, E. |
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リンク | Chemmedchem / PubMed:24000170 |
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手法 | X線回折 |
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解像度 | 1.4 - 1.92 Å |
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構造データ | PDB-4bw1: The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-4bw2: The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-4bw3: The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-4bw4: The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand 手法: X-RAY DIFFRACTION / 解像度: 1.67 Å |
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化合物 | ChemComp-S5B: 4-[(2-tert-butylphenyl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-3-carboxylic acid
ChemComp-UTH: 4-((2-(TERT-BUTYL)PHENYL)AMINO)-7-(3,5-dimethylisoxazol-4-yl)-1,8-naphthyridine-3-carboxylic acid
ChemComp-9BM: 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-1,5-naphthyridine-3-carboxylic acid
ChemComp-9B6: 7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-(2-(trifluoromethoxy)phenyl)-1h-imidazo[4,5-c][1,5]naphthyridin-2(3h)-one
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSCRIPTION / INHIBITOR / HISTONE / EPIGENETIC READER / ANTAGONIST |
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