タイトル | Discovery of an Allosteric Mechanism for the Regulation of Hcv Ns3 Protein Function. |
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ジャーナル・号・ページ | Nat. Chem. Biol., Vol. 8, Page 920-, Year 2012 |
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掲載日 | 2012年8月9日 (構造データの登録日) |
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著者 | Saalau-Bethell, S.M. / Woodhead, A.J. / Chessari, G. / Carr, M.G. / Coyle, J. / Graham, B. / Hiscock, S.D. / Murray, C.W. / Pathuri, P. / Rich, S.J. ...Saalau-Bethell, S.M. / Woodhead, A.J. / Chessari, G. / Carr, M.G. / Coyle, J. / Graham, B. / Hiscock, S.D. / Murray, C.W. / Pathuri, P. / Rich, S.J. / Richardson, C.J. / Williams, P.A. / Jhoti, H. |
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リンク | Nat. Chem. Biol. / PubMed:23023261 |
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手法 | X線回折 |
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解像度 | 2.14 - 2.89 Å |
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構造データ | PDB-4b6e: Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function 手法: X-RAY DIFFRACTION / 解像度: 2.46 Å PDB-4b6f: Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function 手法: X-RAY DIFFRACTION / 解像度: 2.89 Å PDB-4b71: Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-4b73: Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-4b74: Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function 手法: X-RAY DIFFRACTION / 解像度: 2.18 Å PDB-4b75: Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function 手法: X-RAY DIFFRACTION / 解像度: 2.53 Å PDB-4b76: Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function 手法: X-RAY DIFFRACTION / 解像度: 2.14 Å |
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化合物 | ChemComp-DJL: (1R)-1-(4-chloro-2-fluoro-3-phenoxyphenyl)propan-1-aminium
ChemComp-4VA: (2S)-4-amino-N-[(1R)-1-(4-chloro-2-fluoro-3-phenoxyphenyl)propyl]-4-oxobutan-2-aminium
ChemComp-1LH: (2S)-4-[(2-ammonioethyl)amino]-N-[(1R)-1-(4-chloro-2-fluoro-3-phenoxyphenyl)propyl]-4-oxobutan-2-aminium
ChemComp-PW1: [2,4-bis(fluoranyl)-3-phenoxy-phenyl]methylazanium
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由来 | - hepatitis c virus (isolate bk) (C型肝炎ウイルス)
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キーワード | HYDROLASE / HELICASE-PROTEASE / ALLOSTERIC POCKET / FUSION PROTEIN / HCV |
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