タイトル | Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa. |
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ジャーナル・号・ページ | ACS Chem. Biol., Vol. 8, Page 387-396, Year 2013 |
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掲載日 | 2013年2月1日 (構造データの登録日) |
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著者 | Alphey, M.S. / Pirrie, L. / Torrie, L.S. / Boulkeroua, W.A. / Gardiner, M. / Sarkar, A. / Maringer, M. / Oehlmann, W. / Brenk, R. / Scherman, M.S. ...Alphey, M.S. / Pirrie, L. / Torrie, L.S. / Boulkeroua, W.A. / Gardiner, M. / Sarkar, A. / Maringer, M. / Oehlmann, W. / Brenk, R. / Scherman, M.S. / McNeil, M. / Rejzek, M. / Field, R.A. / Singh, M. / Gray, D. / Westwood, N.J. / Naismith, J.H. |
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リンク | ACS Chem. Biol. / PubMed:23138692 |
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手法 | X線回折 |
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解像度 | 1.7 - 2.505 Å |
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構造データ | PDB-3zlk: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.952 Å PDB-3zll: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4arw: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.204 Å PDB-4asj: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-4asy: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-4b2w: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.36 Å PDB-4b2x: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4b3u: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4b42: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.505 Å PDB-4b4b: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4b4g: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-4b4m: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-4b5b: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.055 Å |
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化合物 | ChemComp-Y46: N-(6-AMINO-1-BENZYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)BENZENESULFONAMIDE
ChemComp-4WF: 5-azanyl-6-oxidanyl-1-(phenylmethyl)pyrimidine-2,4-dione
ChemComp-HNR: N-(6-AMINO-1-BUTYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-N-METHYL-BENZENESULFONAMIDE
ChemComp-N6A: N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide
ChemComp-N5Y: N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzamide
ChemComp-BZ0: N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzamide
ChemComp-NIQ: 6-amino-1-butyl-5-(cyclopentylamino)pyrimidine-2,4(1H,3H)-dione
ChemComp-NWL: 6-amino-1-benzyl-5-(ethylamino)pyrimidine-2,4(1H,3H)-dione
ChemComp-942: N-[6-azanyl-1-butyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]-N-methyl-benzamide
ChemComp-GJB: 1-(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione
ChemComp-KKT: N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbutane-1-sulfonamide
ChemComp-JWT: N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-fluoro-N-methylbenzenesulfonamide
ChemComp-BBE: N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N,3-dimethylbenzenesulfonamide
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由来 | pseudomonas aeruginosa pao1 (緑膿菌)![](img/tx_bacteria.gif) pseudomonas aeruginosa (緑膿菌)
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キーワード | TRANSFERASE / THYMIDYLYLTRANSFERASE / ALLOSTERIC INHIBITOR |
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