EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Peptidic Alpha, Beta-Unsaturated Ethyl Esters as Inhibitors of the 3C Protease of Coxsackie Virus B3: Crystal Structures, Antiviral Activities, and Resistance Mutations
ジャーナル・号・ページ	To be Published
掲載日	2011年8月22日 (構造データの登録日)
著者	Tan, J. / Anand, K. / Mesters, J.R. / Hilgenfeld, R.
リンク	PubMedで検索
手法	X線回折
解像度	1.8 - 2.2 Å
構造データ	PDB-3zye: Crystal structure of 3C protease mutant (T68A) of coxsackievirus B3 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-3zz3: Crystal structure of 3C protease mutant (N126Y) of coxsackievirus B3 手法: X-RAY DIFFRACTION / 解像度: 1.89 Å PDB-3zz4: Crystal structure of 3C protease mutant (T68A and N126Y) of coxsackievirus B3 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-3zz5: Crystal structure of 3C protease of coxsackievirus B3 complexed with alpha, beta-unsaturated ethyl ester inhibitor 74 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-3zz7: Crystal structure of 3C protease of coxsackievirus B3 complexed with alpha, beta-unsaturated ethyl ester inhibitor 81 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3zz8: Crystal structure of 3C protease of coxsackievirus B3 complexed with alpha, beta-unsaturated ethyl ester inhibitor 82 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-3zz9: Crystal structure of 3C protease of coxsackievirus B3 complexed with alpha, beta-unsaturated ethyl ester inhibitor 83 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-3zza: Crystal structure of 3C protease of coxsackievirus B3 complexed with alpha, beta-unsaturated ethyl ester inhibitor 84 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3zzb: Crystal structure of 3C protease of coxsackievirus B3 complexed with alpha, beta-unsaturated ethyl ester inhibitor 85 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-3zzc: Crystal structure of 3C protease mutant (T68A and N126Y) of coxsackievirus B3 complexed with alpha, beta-unsaturated ethyl ester inhibitor 83 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-3zzd: Crystal structure of 3C protease mutant (T68A and N126Y) of coxsackievirus B3 complexed with alpha, beta-unsaturated ethyl ester inhibitor 85 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å
化合物	ChemComp-HOH: WATER ChemComp-G74: ETHYL (4R)-4-[(TERT-BUTOXYCARBONYL)AMINO]-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE ChemComp-G81: ETHYL (4R)-4-{[N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANYL]AMINO}-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE ChemComp-G82: ETHYL (5S,8S,11R)-8-BENZYL-5-(3-TERT-BUTOXY-3-OXOPROPYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE ChemComp-G83: ETHYL (5S,8S,11R)-8-BENZYL-5-(2-TERT-BUTOXY-2-OXOETHYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE ChemComp-G84: O-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide ChemComp-G85: N-[(benzyloxy)carbonyl]-O-tert-butyl-L-seryl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide
由来	human coxsackievirus b3 (コクサッキーウイルス) human coxsackievirus (コクサッキーウイルス)
キーワード	HYDROLASE / PICORNAVIRIDAE / BETA-UNSATURATED ETHYL ESTER INHIBITOR