EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses.
ジャーナル・号・ページ	J. Virol., Vol. 87, Page 4339-, Year 2013
掲載日	2011年7月24日 (構造データの登録日)
著者	Tan, J. / George, S. / Kusov, Y. / Perbandt, M. / Anemuller, S. / Mesters, J.R. / Norder, H. / Coutard, B. / Lacroix, C. / Leyssen, P. ...Tan, J. / George, S. / Kusov, Y. / Perbandt, M. / Anemuller, S. / Mesters, J.R. / Norder, H. / Coutard, B. / Lacroix, C. / Leyssen, P. / Neyts, J. / Hilgenfeld, R.
リンク	J. Virol. / PubMed:23388726
手法	X線回折
解像度	1.8 - 2.65 Å
構造データ	PDB-3zv8: Crystal structure of 3C protease of Enterovirus 68 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-3zv9: 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 74 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-3zva: 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 75 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-3zvb: 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 81 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-3zvc: 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 82 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-3zvd: 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 83 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-3zve: 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 84 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3zvf: 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 85 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-3zvg: 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 98 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å
化合物	ChemComp-HOH: WATER ChemComp-G74: ETHYL (4R)-4-[(TERT-BUTOXYCARBONYL)AMINO]-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE ChemComp-G75: ETHYL (4R)-4-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE ChemComp-G81: ETHYL (4R)-4-{[N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANYL]AMINO}-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE ChemComp-G82: ETHYL (5S,8S,11R)-8-BENZYL-5-(3-TERT-BUTOXY-3-OXOPROPYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE ChemComp-G83: ETHYL (5S,8S,11R)-8-BENZYL-5-(2-TERT-BUTOXY-2-OXOETHYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE ChemComp-G84: O-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide ChemComp-G85: N-[(benzyloxy)carbonyl]-O-tert-butyl-L-seryl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide ChemComp-G86: N-(tert-butoxycarbonyl)-O-tert-butyl-L-threonyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide
由来	human enterovirus (エンテロウイルス) enterovirus d68 (エンテロウイルス)
キーワード	HYDROLASE / MICHAEL INHIBITOR