タイトル | X-ray structure of p38 alpha bound to TAK-715: comparison with three classic inhibitors. |
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ジャーナル・号・ページ | Acta Crystallogr. D Biol. Crystallogr., Vol. 68, Page 1041-1050, Year 2012 |
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掲載日 | 2011年6月23日 (構造データの登録日) |
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著者 | Azevedo, R. / van Zeeland, M. / Raaijmakers, H. / Kazemier, B. / de Vlieg, J. / Oubrie, A. |
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リンク | Acta Crystallogr. D Biol. Crystallogr. / PubMed:22868770 |
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手法 | X線回折 |
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解像度 | 1.6 - 2.4 Å |
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構造データ | PDB-3zs5: Structural basis for kinase selectivity of three clinical p38alpha inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-3zsg: X-ray structure of p38alpha bound to TAK-715 手法: X-RAY DIFFRACTION / 解像度: 1.89 Å PDB-3zsh: X-ray structure of p38alpha bound to SCIO-469 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-3zsi: X-ray structure of p38alpha bound to VX-745 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å |
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化合物 | ChemComp-SB2: 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
ChemComp-469: 2-(6-chloro-5-{[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]carbonyl}-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide
ChemComp-52P: 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one / VX-745
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / TAK-715 / SCIO-469 / VX-745 / SB-203580 |
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