EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Squalene synthase as a target for Chagas disease therapeutics.
ジャーナル・号・ページ	Plos Pathog., Vol. 10, Page e1004114-e1004114, Year 2014
掲載日	2013年5月26日 (構造データの登録日)
著者	Shang, N. / Li, Q. / Ko, T.P. / Chan, H.C. / Li, J. / Zheng, Y. / Huang, C.H. / Ren, F. / Chen, C.C. / Zhu, Z. ...Shang, N. / Li, Q. / Ko, T.P. / Chan, H.C. / Li, J. / Zheng, Y. / Huang, C.H. / Ren, F. / Chen, C.C. / Zhu, Z. / Galizzi, M. / Li, Z.H. / Rodrigues-Poveda, C.A. / Gonzalez-Pacanowska, D. / Veiga-Santos, P. / de Carvalho, T.M. / de Souza, W. / Urbina, J.A. / Wang, A.H. / Docampo, R. / Li, K. / Liu, Y.L. / Oldfield, E. / Guo, R.T.
リンク	Plos Pathog. / PubMed:24789335
手法	X線回折
解像度	2.06 - 3 Å
構造データ	PDB-3wc9: The complex structure of HsSQS wtih ligand, FSPP 手法: X-RAY DIFFRACTION / 解像度: 2.82 Å PDB-3wca: The complex structure of TcSQS with ligand, FSPP 手法: X-RAY DIFFRACTION / 解像度: 2.24 Å PDB-3wcb: The complex structure of TcSQS with ligand, BPH1237 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-3wcc: The complex structure of TcSQS with ligand, E5700 手法: X-RAY DIFFRACTION / 解像度: 2.32 Å PDB-3wcd: The complex structure of HsSQS wtih ligand, WC-9 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-3wce: The complex structure of TcSQS with ligand, ER119884 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-3wcf: The complex structure of HsSQS wtih ligand,BPH1218 手法: X-RAY DIFFRACTION / 解像度: 2.22 Å PDB-3wcg: The complex structure of TcSQS with ligand, BPH1344 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-3wch: The complex structure of HsSQS wtih ligand BPH1237 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-3wci: The complex structure of HsSQS wtih ligand,BPH1325 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-3wcj: The complex structure of HsSQS wtih ligand,E5700 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-3wcl: The complex structure of HsSQS wtih ligand,BPH1344 手法: X-RAY DIFFRACTION / 解像度: 2.24 Å PDB-3wcm: The complex structure of HsSQS wtih ligand, ER119884 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å
化合物	ChemComp-FPS: S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE / チオピロりん酸ファルネシル ChemComp-HOH: WATER ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-8PH: hydrogen [(1R)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-hydroxy-1-phosphonoethyl]phosphonate ChemComp-E5S: (3R)-3-({2-benzyl-6-[(3R,4S)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridin-3-yl}ethynyl)-1-azabicyclo[2.2.2]octan-3-ol / E-5700 ChemComp-RWY: 2-(4-phenoxyphenoxy)ethyl thiocyanate / 2-(4-フェノキシフェノキシ)エチルチオシアナ-ト ChemComp-ER4: (3R)-3-{[2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl]ethynyl}-1-azabicyclo[2.2.2]octan-3-ol / ER-119884 ChemComp-BH8: hydrogen [(1S)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate ChemComp-BH3: hydrogen [(1R)-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate ChemComp-BH5: hydrogen [(1R)-1-hydroxy-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate
由来	homo sapiens (ヒト) trypanosoma cruzi (トリパノソーマ)
キーワード	TRANSFERASE / isoprenoids / drug discovery / human squalene synthase / FSPP / Trypanosoma cruzi squalene synthase / BPH-1237 / E5700 / WC-9 / ER-119884 / BPH1218 / BPH-1344 / BPH1237 / BPH1325 / ER119884