EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
ジャーナル・号・ページ	J. Med. Chem., Vol. 55, Page 2641-2648, Year 2012
掲載日	2012年1月2日 (構造データの登録日)
著者	Good, A.C. / Liu, J. / Hirth, B. / Asmussen, G. / Xiang, Y. / Biemann, H.P. / Bishop, K.A. / Fremgen, T. / Fitzgerald, M. / Gladysheva, T. ...Good, A.C. / Liu, J. / Hirth, B. / Asmussen, G. / Xiang, Y. / Biemann, H.P. / Bishop, K.A. / Fremgen, T. / Fitzgerald, M. / Gladysheva, T. / Jain, A. / Jancsics, K. / Metz, M. / Papoulis, A. / Skerlj, R. / Stepp, J.D. / Wei, R.R.
リンク	J. Med. Chem. / PubMed:22339127
手法	X線回折
解像度	1.85 - 2.48 Å
構造データ	PDB-3vbq: Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-3vbt: Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 手法: X-RAY DIFFRACTION / 解像度: 2.23 Å PDB-3vbv: Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 手法: X-RAY DIFFRACTION / 解像度: 2.08 Å PDB-3vbw: Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 手法: X-RAY DIFFRACTION / 解像度: 2.48 Å PDB-3vbx: Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 手法: X-RAY DIFFRACTION / 解像度: 2.03 Å PDB-3vby: Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 手法: X-RAY DIFFRACTION / 解像度: 2.27 Å PDB-3vc4: Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 手法: X-RAY DIFFRACTION / 解像度: 2.23 Å
化合物	ChemComp-0F5: (5~{Z})-5-[[3-[6-[(4-azanylcyclohexyl)amino]pyrazin-2-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione ChemComp-HOH: WATER ChemComp-0F9: 4-chloro-2-(1H-pyrazol-3-yl)phenol / 2-(1H-ピラゾ-ル-5-イル)-4-クロロフェノ-ル ChemComp-0FK: 8-hydroxyquinoline-2-carboxamide ChemComp-0FN: 1,3-dioxo-2,3-dihydro-1H-indene-2-carbonitrile / 1,3-ジオキソインダン-2-カルボニトリル ChemComp-0FO: 6-bromo-4-hydroxy-2H-chromen-2-one / 4-ヒドロキシ-6-ブロモ-2H-1-ベンゾピラン-2-オン ChemComp-0FR: furan-2-yl(1H-indol-3-yl)methanone / 2-フラニル(1H-インド-ル-3-イル)ケトン ChemComp-IMD: IMIDAZOLE / 1H-イミダゾ-ル-3-カチオン ChemComp-0FS: (5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione / 5-[3-(トリフルオロメチル)ベンジリデン]チアゾリジン-2,4-ジオン
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE/TRANSFERASE INHIBITOR / Pim1 / Rossmann Fold / TRANSFERASE-TRANSFERASE INHIBITOR complex