タイトル | Gaining insight into the inhibition of glycoside hydrolase family 20 exo-beta-N-acetylhexosaminidases using a structural approach |
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ジャーナル・号・ページ | Org. Biomol. Chem., Vol. 10, Page 2607-2612, Year 2012 |
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掲載日 | 2011年7月11日 (構造データの登録日) |
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著者 | Sumida, T. / Stubbs, K.A. / Ito, M. / Yokoyama, S. |
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リンク | Org. Biomol. Chem. / PubMed:22367352 |
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手法 | X線回折 |
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解像度 | 1.6 - 1.9 Å |
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構造データ | PDB-3sur: Crystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with NAG-thiazoline. 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-3sus: Crystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with Gal-NAG-thiazoline 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3sut: Crystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with PUGNAc 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-3suu: Crystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with Gal-PUGNAc 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-3suv: Crystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with NHAc-DNJ 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-3suw: Crystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with NHAc-CAS 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å |
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化合物 | ChemComp-NGT: 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL / NAG-チアゾリン
ChemComp-GNL: (3aR,5R,6R,7R,7aR)-5-(hydroxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
ChemComp-OAN: O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE / PUGNAc / 阻害剤*YM
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由来 | paenibacillus (バクテリア)
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キーワード | HYDROLASE / Structural Genomics / RIKEN Structural Genomics/Proteomics Initiative / RSGI / Tim Barrel / Carbohydrate/Sugar Binding / HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex |
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