タイトル | Lysine Nzeta-decarboxylation switch and activation of the beta-lactam sensor domain of BlaR1 protein of methicillin-resistant Staphylococcus aureus. |
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ジャーナル・号・ページ | J. Biol. Chem., Vol. 286, Page 31466-31472, Year 2011 |
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掲載日 | 2011年1月5日 (構造データの登録日) |
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著者 | Borbulevych, O. / Kumarasiri, M. / Wilson, B. / Llarrull, L.I. / Lee, M. / Hesek, D. / Shi, Q. / Peng, J. / Baker, B.M. / Mobashery, S. |
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リンク | J. Biol. Chem. / PubMed:21775440 |
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手法 | X線回折 |
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解像度 | 1.87 - 2.1 Å |
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構造データ | PDB-3q7v: Beta-Lactam-Sensor Domain of BlaR1 (Apo) from Staphylococcus Aureus with Carboxylated Lys392 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-3q7z: CBAP-acylated BlaR1 sensor domain from Staphylococcus aureus 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-3q81: Imipenem acylated BlaR1 sensor domain from Staphylococcus aureus 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-3q82: Meropenem acylated BlaR1 sensor domain from Staphylococcus aureus 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å |
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化合物 | ChemComp-BOU: (2R,4S)-2-[(1R)-1-{[(2'-carboxybiphenyl-2-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic
ChemComp-IM2: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox / 抗生剤*YM
ChemComp-MER: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d / 抗生剤*YM
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由来 | ![](img/tx_bacteria.gif) staphylococcus aureus (黄色ブドウ球菌)
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キーワード | HYDROLASE REGULATOR / antibiotic-binding / MRSA / HYDROLASE REGULATOR/ANTIBIOTIC / antibiotic-binding-antibiotic complex / HYDROLASE REGULATOR-ANTIBIOTIC complex |
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