EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
ジャーナル・号・ページ	Protein Sci., Vol. 20, Page 428-436, Year 2011
掲載日	2010年11月8日 (構造データの登録日)
著者	Kuglstatter, A. / Wong, A. / Tsing, S. / Lee, S.W. / Lou, Y. / Villasenor, A.G. / Bradshaw, J.M. / Shaw, D. / Barnett, J.W. / Browner, M.F.
リンク	Protein Sci. / PubMed:21280133
手法	X線回折
解像度	1.75 - 2.55 Å
構造データ	PDB-3pix: Crystal structure of BTK kinase domain complexed with 2-Isopropyl-7-(4-methyl-piperazin-1-yl)-4-(5-methyl-2H-pyrazol-3-ylamino)-2H-phthalazin-1-one 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-3piy: Crystal structure of BTK kinase domain complexed with R406 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å PDB-3piz: Crystal structure of BTK kinase domain complexed with (5-Amino-1-o-tolyl-1H-pyrazol-4-yl)-[3-(1-methanesulfonyl-piperidin-4-yl)-phenyl]-methanone 手法: X-RAY DIFFRACTION / 解像度: 2.21 Å PDB-3pj1: Crystal structure of BTK kinase domain complexed with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-3pj2: Crystal structure of BTK kinase domain complexed with 2-[4-(2-Diethylamino-ethoxy)-phenylamino]-6-(4-fluoro-phenoxy)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-3pj3: Crystal structure of BTK kinase domain complexed with 2-Methyl-5-[(E)-(3-phenyl-acryloyl)amino]-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-benzamide 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å
化合物	ChemComp-027: 7-(4-methylpiperazin-1-yl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-(propan-2-yl)phthalazin-1(2H)-one ChemComp-HOH: WATER ChemComp-585: 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one / 6-[[5-フルオロ-2-[(3,4,5-トリメトキシフェニル)アミノ]-4-ピリミジニル]アミノ]-2,2-ジメチル(以下略) ChemComp-03C: [5-amino-1-(2-methylphenyl)-1H-pyrazol-4-yl]{3-[1-(methylsulfonyl)piperidin-4-yl]phenyl}methanone ChemComp-LHL: 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one ChemComp-04K: 2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-6-(4-fluorophenoxy)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one ChemComp-04L: 2-methyl-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-5-{[(2E)-3-phenylprop-2-enoyl]amino}benzamide
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE/INHIBITOR / helix C-out / DFG-in / TRANSFERASE / TRANSFERASE-INHIBITOR complex / helix C-in / DFG-out