タイトル | Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. USA, Vol. 107, Page 22002-22007, Year 2010 |
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掲載日 | 2010年10月20日 (構造データの登録日) |
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著者 | Han, S. / Zaniewski, R.P. / Marr, E.S. / Lacey, B.M. / Tomaras, A.P. / Evdokimov, A. / Miller, J.R. / Shanmugasundaram, V. |
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リンク | Proc. Natl. Acad. Sci. USA / PubMed:21135211 |
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手法 | X線回折 |
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解像度 | 1.641 - 2 Å |
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構造データ | PDB-3pbn: Crystal Structure of Apo PBP3 from Pseudomonas aeruginosa 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-3pbo: Crystal structure of PBP3 complexed with ceftazidime 手法: X-RAY DIFFRACTION / 解像度: 1.74 Å PDB-3pbq: Crystal structure of PBP3 complexed with imipenem 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-3pbr: Crystal structure of PBP3 complexed with meropenem 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-3pbs: Crystal structure of PBP3 complexed with aztreonam 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-3pbt: Crystal structure of PBP3 complexed with MC-1 手法: X-RAY DIFFRACTION / 解像度: 1.641 Å |
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化合物 | ChemComp-IM2: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox / 抗生剤*YM
ChemComp-MER: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d / 抗生剤*YM
ChemComp-AZR: 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid / 抗生剤*YM
ChemComp-UE1: (4S,7Z)-7-(2-amino-1,3-thiazol-4-yl)-1-[({4-[(2R)-2,3-dihydroxypropyl]-3-(4,5-dihydroxypyridin-2-yl)-5-oxo-4,5-dihydro-
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由来 | - pseudomonas aeruginosa (緑膿菌)
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キーワード | HYDROLASE/ANTIBIOTIC / PBP3 / HYDROLASE-ANTIBIOTIC complex / PBP |
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