タイトル Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome. ジャーナル・号・ページ Bioorg. Med. Chem. Lett. , Vol. 20, Page 6581-6586, Year 2010掲載日 2010年8月13日 (構造データの登録日) 著者Blackburn, C. / Barrett, C. / Blank, J.L. / Bruzzese, F.J. / Bump, N. / Dick, L.R. / Fleming, P. / Garcia, K. / Hales, P. / Hu, Z. ...Blackburn, C. / Barrett, C. / Blank, J.L. / Bruzzese, F.J. / Bump, N. / Dick, L.R. / Fleming, P. / Garcia, K. / Hales, P. / Hu, Z. / Jones, M. / Liu, J.X. / Sappal, D.S. / Sintchak, M.D. / Tsu, C. / Gigstad, K.M. リンク Bioorg. Med. Chem. Lett. / PubMed:20875739手法 X線回折 解像度 2.6 - 2.85 Å 構造データ PDB-3oeu : 構造ビューア Structure of yeast 20S open-gate proteasome with Compound 24 手法 : X-RAY DIFFRACTION / 解像度 : 2.6 Å
PDB-3oev : 構造ビューア Structure of yeast 20S open-gate proteasome with Compound 25 手法 : X-RAY DIFFRACTION / 解像度 : 2.85 Å
PDB-3sdi : 構造ビューア Structure of yeast 20S open-gate proteasome with Compound 20 手法 : X-RAY DIFFRACTION / 解像度 : 2.65 Å
PDB-3sdk : 構造ビューア Structure of yeast 20S open-gate proteasome with Compound 34 手法 : X-RAY DIFFRACTION / 解像度 : 2.7 Å
化合物 ChemComp-OEU : 構造ビューア N-{(2S)-1-[(2-chlorobenzyl)amino]-1-oxo-4-phenylbutan-2-yl}-N~2~-[3-(2-methylphenyl)propanoyl]-L-threoninamide
ChemComp-3OE : 構造ビューア 4-(benzyloxy)-N-[(2S,3R)-3-hydroxy-1-{[(2S)-1-{[(3-methylthiophen-2-yl)methyl]amino}-1-oxo-4-phenylbutan-2-yl]amino}-1-oxobutan-2-yl]benzamide
ChemComp-3SD : 構造ビューア N~4~-(2,2-dimethylpropyl)-N~1~-{(2S)-1-[(4-methylbenzyl)amino]-1-oxo-4-phenylbutan-2-yl}-N~2~-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-aspartamide
ChemComp-P3N : 構造ビューア N-[(2S)-3-(3-tert-butyl-1,2,4-oxadiazol-5-yl)-1-({(2S)-1-[(4-methylbenzyl)amino]-1-oxo-4-phenylbutan-2-yl}amino)-1-oxopropan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide
由来 saccharomyces cerevisiae (パン酵母) キーワード Hydrolase/Hydrolase Inhibitor / 20S proteasome / Hydrolase-Hydrolase Inhibitor complex