EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design
ジャーナル・号・ページ	ANTIVIR. CHEM. CHEMOTHER., Vol. 21, Page 155-168, Year 2011
掲載日	2010年6月9日 (構造データの登録日)
著者	Rhodes, D.I. / Peat, T.S. / Vandegraaff, N. / Jeevarajah, D. / Le, G. / Jones, E.D. / Smith, J.A. / Coates, J.A. / Winfield, L.J. / Thienthong, N. ...Rhodes, D.I. / Peat, T.S. / Vandegraaff, N. / Jeevarajah, D. / Le, G. / Jones, E.D. / Smith, J.A. / Coates, J.A. / Winfield, L.J. / Thienthong, N. / Newman, J. / Lucent, D. / Ryan, J.H. / Savage, G.P. / Francis, C.L. / Deadman, J.J.
リンク	ANTIVIR. CHEM. CHEMOTHER. / PubMed:21602613
手法	X線回折
解像度	1.8 - 1.95 Å
構造データ	PDB-3nf6: Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-3nf7: Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3nf8: Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-3nf9: Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-3nfa: Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å
化合物	ChemComp-SO4: SULFATE ION / 硫酸ジアニオン / 硫酸塩 ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル / エチレングリコール ChemComp-CL: Unknown entry / クロリド / 塩化物 ChemComp-ACY: ACETIC ACID / 酢酸 / 酢酸 ChemComp-IMV: 5-[(2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]-1,3-benzodioxole-4-carboxylic acid ChemComp-HOH: WATER / 水 ChemComp-CIW: 5-[(5-chloro-2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]-1,3-benzodioxole-4-carboxylic acid ChemComp-CDQ: 6-[(5-chloro-2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid ChemComp-CD9: 5-[(6-chloro-2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]-1,3-benzodioxole-4-carboxylic acid ChemComp-CBJ: 6-[(5-bromo-2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid
由来	human immunodeficiency virus 1 (ヒト免疫不全ウイルス)
キーワード	HYDROLASE/HYDROLASE INHIBITOR / integrase (インテグラーゼ) / integration / DNA (デオキシリボ核酸) / see mutations / intra-cellular / HYDROLASE-HYDROLASE INHIBITOR complex