タイトル | Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha |
---|
ジャーナル・号・ページ | To be Published |
---|
掲載日 | 2010年1月16日 (構造データの登録日) |
---|
著者 | Getlik, M. / Gruetter, C. / Simard, J.R. / Van Otterlo, W. / Robubi, A. / Aust, B. / Rauh, D. |
---|
リンク | PubMedで検索 |
---|
手法 | X線回折 |
---|
解像度 | 1.5 - 3.4 Å |
---|
構造データ | PDB-3lfa: Human p38 MAP Kinase in Complex with Dasatinib 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-3lfb: Human p38 MAP Kinase in Complex with RL98 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-3lfc: Human p38 MAP Kinase in Complex with RL99 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-3lfd: Human p38 MAP Kinase in Complex with RL113 手法: X-RAY DIFFRACTION / 解像度: 3.4 Å PDB-3lfe: Human p38 MAP Kinase in Complex with RL116 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-3lff: Human p38 MAP Kinase in Complex with RL166 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å |
---|
化合物 | ChemComp-1N1: N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE / ダサチニブ / 薬剤*YM
ChemComp-Z87: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(1,3-thiazol-2-yl)urea
ChemComp-Z86: (4-{5-[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}carbamoyl)amino]-3-tert-butyl-1H-pyrazol-1-yl}phenyl)acetic acid
ChemComp-Z85: 1-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea
ChemComp-Z83: (4-{3-tert-butyl-5-[(1,3-thiazol-2-ylcarbamoyl)amino]-1H-pyrazol-1-yl}phenyl)acetic acid
|
---|
由来 | homo sapiens (ヒト)
|
---|
キーワード | TRANSFERASE / Thiazole-urea / DFG-out / SAR / ATP-binding / Kinase / Nucleotide-binding / Nucleus / Phosphoprotein / Serine/threonine-protein kinase |
---|